BRENDA - Enzyme Database
show all sequences of 1.5.1.25

Lysine metabolism in mammalian brain an update on the importance of recent discoveries

Hallen, A.; Jamie, J.F.; Cooper, A.J.; Amino Acids 45, 1249-1272 (2013)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Bos taurus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Homo sapiens
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Macropus giganteus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Mus musculus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3, especially at neutral pH, reversible inhibition
Rattus norvegicus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Macropus giganteus
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Sus scrofa
5829
-
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-piperideine 2-carboxylate + NADPH + H+
Homo sapiens
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Mus musculus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Rattus norvegicus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Sus scrofa
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Bos taurus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Macropus giganteus
-
L-pipecolate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Mus musculus
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Homo sapiens
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Rattus norvegicus
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Macropus giganteus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
purified from bovine brain
Bos taurus
purified from lamb brain
Macropus giganteus
purified from porcine kidney
Sus scrofa
purified from rat liver
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
very low expression in cerebellum compared to cerebrum, high overall expression level
Mus musculus
-
brain
levels of thyroid hormone binding capacity for cytosolic NADPH-dependent T3 binding are noticeably lower in the cerebellum than in the cerebrum of adult rat brain at all stages of development. NADPH-dependent T3 binding is only detected in kidney, liver, heart and spleen after birth, increasing over the next 6 weeks. NADPH-dependent T3 binding is detected in cerebrum and cerebellum 5 days before birth, increasing with a sharp transient spike at the time of birth, that is specific for the brain, particularly in cerebrum, and cannot be seen in other tissues. The NADPH-dependent T3 binding in cerebrum decreases after birth, but begins to increase again 2 weeks after birth. The level in cerebellum does not show this increase. The brain may contain at least two distinct P2C reductases/ketimine reductase, one of which is predominant in the fore-brain and another that is prominent in the cerebellum
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Bos taurus
-
brain
-
Homo sapiens
-
cerebellum
-
Mus musculus
-
cerebellum
-
Rattus norvegicus
-
cerebrum
-
Mus musculus
-
cerebrum
-
Rattus norvegicus
-
heart
high enzyme expression level
Mus musculus
-
inner ear
-
Homo sapiens
-
kidney
-
Sus scrofa
-
lens
-
Macropus giganteus
-
liver
-
Rattus norvegicus
-
additional information
CRYM/KR mRNA in the mouse is most highly expressed in skin among the tissues evaluated, followed by brain and heart
Mus musculus
-
skin
high enzyme expression level, expression of the CRYM transcript follows the hair growth cycle with a significant increase in expression during mid- and late anagen growth phases
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
highly purified recombinantly expressed human CRYM possesses substantial ketimine reductase activity
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-piperideine 2-carboxylate + NADPH + H+
-
741580
Homo sapiens
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Mus musculus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Rattus norvegicus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Sus scrofa
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Bos taurus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Macropus giganteus
L-pipecolate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Mus musculus
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Homo sapiens
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Rattus norvegicus
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
about, with substrate 1-piperideine 2-carboxylate
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Macropus giganteus
NADPH
-
Rattus norvegicus
NADPH
-
Sus scrofa
NADPH
-
Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000278
-
3,5,3'-triiodothyronine
with substrate S-(2-aminoethyl)-L-cysteine ketimine, pH 5.0, temperature not specified in the publication
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Macropus giganteus
NADPH
-
Rattus norvegicus
NADPH
-
Sus scrofa
NADPH
-
Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Bos taurus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Homo sapiens
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Macropus giganteus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Mus musculus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3, especially at neutral pH, reversible inhibition
Rattus norvegicus
3,5,3'-triiodothyronine
the ketimine reductase activity of CRYM is strongly inhibited by the thyroid hormone T3
Sus scrofa
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000278
-
3,5,3'-triiodothyronine
with substrate S-(2-aminoethyl)-L-cysteine ketimine, pH 5.0, temperature not specified in the publication
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Macropus giganteus
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Sus scrofa
5829
-
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-piperideine 2-carboxylate + NADPH + H+
Homo sapiens
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Mus musculus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Rattus norvegicus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Sus scrofa
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Bos taurus
-
L-pipecolate + NADP+
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
Macropus giganteus
-
L-pipecolate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Mus musculus
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Homo sapiens
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
Rattus norvegicus
-
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
purified from bovine brain
Bos taurus
purified from lamb brain
Macropus giganteus
purified from porcine kidney
Sus scrofa
purified from rat liver
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
very low expression in cerebellum compared to cerebrum, high overall expression level
Mus musculus
-
brain
levels of thyroid hormone binding capacity for cytosolic NADPH-dependent T3 binding are noticeably lower in the cerebellum than in the cerebrum of adult rat brain at all stages of development. NADPH-dependent T3 binding is only detected in kidney, liver, heart and spleen after birth, increasing over the next 6 weeks. NADPH-dependent T3 binding is detected in cerebrum and cerebellum 5 days before birth, increasing with a sharp transient spike at the time of birth, that is specific for the brain, particularly in cerebrum, and cannot be seen in other tissues. The NADPH-dependent T3 binding in cerebrum decreases after birth, but begins to increase again 2 weeks after birth. The level in cerebellum does not show this increase. The brain may contain at least two distinct P2C reductases/ketimine reductase, one of which is predominant in the fore-brain and another that is prominent in the cerebellum
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Bos taurus
-
brain
-
Homo sapiens
-
cerebellum
-
Mus musculus
-
cerebellum
-
Rattus norvegicus
-
cerebrum
-
Mus musculus
-
cerebrum
-
Rattus norvegicus
-
heart
high enzyme expression level
Mus musculus
-
inner ear
-
Homo sapiens
-
kidney
-
Sus scrofa
-
lens
-
Macropus giganteus
-
liver
-
Rattus norvegicus
-
additional information
CRYM/KR mRNA in the mouse is most highly expressed in skin among the tissues evaluated, followed by brain and heart
Mus musculus
-
skin
high enzyme expression level, expression of the CRYM transcript follows the hair growth cycle with a significant increase in expression during mid- and late anagen growth phases
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
highly purified recombinantly expressed human CRYM possesses substantial ketimine reductase activity
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-piperideine 2-carboxylate + NADPH + H+
-
741580
Homo sapiens
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Mus musculus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Rattus norvegicus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Sus scrofa
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Bos taurus
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
-
741580
Macropus giganteus
L-pipecolate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Mus musculus
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Homo sapiens
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
-
741580
Rattus norvegicus
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
about, with substrate 1-piperideine 2-carboxylate
Homo sapiens
Expression
Organism
Commentary
Expression
Bos taurus
steroid hormones have a marked effect on the expression of CRYM, e.g. androgens induce CRYM expression in bovine mammary glands
up
Homo sapiens
steroid hormones have a marked effect on the expression of CRYM, e.g. androgens induce CRYM expression in human prostate cancer
up
General Information
General Information
Commentary
Organism
malfunction
Significance of CRYM/KR in psychiatric and neurological disease, overview. Two known point mutations of human CRYM, both of which are associated with nonsyndromic deafness
Homo sapiens
malfunction
significance of CRYM/KR in psychiatric and neurological disease, overview
Mus musculus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Bos taurus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Homo sapiens
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Macropus giganteus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Mus musculus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Rattus norvegicus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Sus scrofa
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Bos taurus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity. Levels of CRYM/KR substrates are important determinants in hearing as CRYM mRNA is highly expressed in human inner ear
Homo sapiens
physiological function
the thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Macropus giganteus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity. Possible involvement of CRYM in the development of mouse hair follicles during the anagen phase. Enzyme substrates (e.g. sulfur-containing cyclic ketimines such as S-(2-aminoethyl)-L-cysteine ketimine) may play a role in regulating cell growth and/or cell differentiation
Mus musculus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Rattus norvegicus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Sus scrofa
General Information (protein specific)
General Information
Commentary
Organism
malfunction
Significance of CRYM/KR in psychiatric and neurological disease, overview. Two known point mutations of human CRYM, both of which are associated with nonsyndromic deafness
Homo sapiens
malfunction
significance of CRYM/KR in psychiatric and neurological disease, overview
Mus musculus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Bos taurus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Homo sapiens
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Macropus giganteus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Mus musculus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Rattus norvegicus
metabolism
the enzyme is involved in the pipecolate pathway, i.e. P2C reductase activity
Sus scrofa
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Bos taurus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity. Levels of CRYM/KR substrates are important determinants in hearing as CRYM mRNA is highly expressed in human inner ear
Homo sapiens
physiological function
the thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Macropus giganteus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity. Possible involvement of CRYM in the development of mouse hair follicles during the anagen phase. Enzyme substrates (e.g. sulfur-containing cyclic ketimines such as S-(2-aminoethyl)-L-cysteine ketimine) may play a role in regulating cell growth and/or cell differentiation
Mus musculus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Rattus norvegicus
physiological function
mammalian thyroid hormone-binding protein CRYM has an additional biological role as a ketimine reductase, CRYM is a P2C reductase. CRYM shows an extremely strong affinity for 3,5,3'-triiodothyronine T3 in the presence of NADPH. The enzyme seems to be tightly regulated in vivo by 3,5,3'-triiodothyronine (T3) at low concentrations, T3 bioavailability is likely strongly dependent on the pipecolate pathway activity
Sus scrofa
Expression (protein specific)
Organism
Commentary
Expression
Bos taurus
steroid hormones have a marked effect on the expression of CRYM, e.g. androgens induce CRYM expression in bovine mammary glands
up
Homo sapiens
steroid hormones have a marked effect on the expression of CRYM, e.g. androgens induce CRYM expression in human prostate cancer
up
Other publictions for EC 1.5.1.25
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741584
Hallen
Ketimine reductase/CRYM catal ...
Homo sapiens
Amino Acids
47
2457-2461
2015
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
7
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
743354
Hallen
Insights into enzyme catalysi ...
Bos taurus, Homo sapiens, Mus musculus
Neurochem. Res.
40
1252-1266
2015
-
-
-
-
-
-
20
5
3
-
-
15
-
3
-
-
-
3
-
3
-
-
16
-
1
-
-
4
3
-
-
3
6
-
1
-
-
-
3
-
-
-
1
20
6
5
3
-
-
15
-
-
-
-
-
3
-
-
16
-
1
-
-
4
3
-
-
-
-
4
4
-
4
4
741580
Hallen
Lysine metabolism in mammalia ...
Bos taurus, Homo sapiens, Macropus giganteus, Mus musculus, Rattus norvegicus, Sus scrofa
Amino Acids
45
1249-1272
2013
-
-
-
-
-
-
6
-
6
-
-
9
-
6
-
-
4
-
-
16
1
-
9
-
-
-
-
-
1
-
-
6
1
-
-
-
-
-
6
-
-
-
-
6
1
-
6
-
-
9
-
-
-
4
-
16
1
-
9
-
-
-
-
-
1
-
-
-
2
14
14
2
-
-
440358
Nardini
Purification and characterizat ...
Sus scrofa
Eur. J. Biochem.
173
689-694
1988
-
-
-
-
-
1
1
4
-
-
2
-
-
3
-
-
1
1
-
1
1
-
8
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
2
-
-
1
-
1
-
4
-
-
2
-
-
-
-
1
-
1
1
-
8
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
440359
Nardini
Bovine brain ketimine reductas ...
Bos taurus
Biochim. Biophys. Acta
957
286-292
1988
-
-
-
-
-
-
-
6
1
-
2
-
-
1
-
-
1
1
-
1
1
1
8
1
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
6
1
-
2
-
-
-
-
1
-
1
1
1
8
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-