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Literature summary for 1.5.1.22 extracted from

  • Fields, J.H.A.; Storey, K.B.
    Tissue-specific alanopine dehydrogenase from the gill and strombine dehydrogenase from the foot muscle of the cherrystone clam Mercenaria mercenaria (1987), J. Exp. Mar. Biol. Ecol., 105, 175-185.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
D-lactate weak Mercenaria mercenaria
L-lactate weak Mercenaria mercenaria
meso-Alanopine weak Mercenaria mercenaria
succinate weak Mercenaria mercenaria

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.32
-
pyruvate
-
Mercenaria mercenaria
0.61
-
pyruvate
-
Mercenaria mercenaria
2.46
-
2-oxobutanoate
-
Mercenaria mercenaria
4.18
-
glyoxylate
-
Mercenaria mercenaria
44
-
L-2-aminobutanoate
-
Mercenaria mercenaria
173
-
L-Ala
-
Mercenaria mercenaria
242
-
L-Ala
-
Mercenaria mercenaria
693
-
L-Ser
-
Mercenaria mercenaria

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mercenaria mercenaria the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia ?
-
?

Organism

Organism UniProt Comment Textmining
Mercenaria mercenaria
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Mercenaria mercenaria

Source Tissue

Source Tissue Comment Organism Textmining
foot muscle
-
Mercenaria mercenaria
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly + 2-oxobutanoate + NADH 30% of the activity with pyruvate Mercenaria mercenaria ?
-
?
Gly + glyoxylate + NADH 20% of the activity with pyruvate Mercenaria mercenaria ?
-
?
Gly + pyruvate + NADH
-
Mercenaria mercenaria D-Strombine + NAD+ + H2O
-
?
L-2-Aminobutanoate + pyruvate + NADH at 48% of the activity with Gly Mercenaria mercenaria ?
-
?
L-Ala + pyruvate + NADH at 76% of the activity with Gly Mercenaria mercenaria meso-Alanopine + NAD+ + H2O
-
?
L-Ser + pyruvate + NADH at 82% of the activity with Gly Mercenaria mercenaria ?
-
?
additional information the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia Mercenaria mercenaria ?
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mercenaria mercenaria
NADH
-
Mercenaria mercenaria