Literature summary for 1.5.1.20 extracted from

Szamosi, S.; Csiki, Z.; Szomjak, E.; Szolnoki, E.; Szoke, G.; Szekanecz, Z.; Szegedi, G.; Shoenfeld, Y.; Szucs, G.
Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage? (2009), Clin. Rev. Allergy Immunol., 36, 145-149.

Search for more literature for 1.5.1.20

Application

Application	Comment	Organism
medicine	no significant differences in plasma homocysteine levels and MTHFR genotypes are found in patients with systemic sclerosis compared to controls or in systemic sclerosis patients with limited cutaneous compared to diffuse disease. Seventy-one percent of patients with macrovascular disorders have MTHFR polymorphism C677T. In addition, 45% of patients with hyperhomocysteinemia have pulmonary hypertension. The presence of MTHFR C677T mutation influences the incidence of macrovascular abnormalities in SSc patients	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C677T	seventy-one percent of patients with macrovascular disorders have the MTHFR polymorphism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with systemic sclerosis	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)