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Literature summary for 1.5.1.20 extracted from
- Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer (2007), Pharmacogenomics, 8, 1561-1566.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the consequences of a deficient MTHFR genotype are probably dependent on the folate intake status, there is no clear conclusion regarding the influence of MTHFR polymorphisms on 5-fluorouracil-based treatment in colorectal cancer | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the MTHFR gene polymorphisms C677T and A1298C are associated with altered enzyme activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + reduced acceptor | - |
Homo sapiens | 5-methyltetrahydrofolate + oxidized acceptor | - |
ir |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate reductase | - |
Homo sapiens |
| MTHFR | - |
Homo sapiens |
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