Literature summary for 1.5.1.20 extracted from

Li, D.; Karp, N.; Wu, Q.; Wang, X.L.; Melnyk, S.; James, S.J.; Rozen, R.
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency (2008), J. Inherit. Metab. Dis., 31, 403-411.

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Application

Application	Comment	Organism
medicine	MTHFR is important for postnatal growth and vitality and 5-methyltetrahydrofolate deficiency contributes to the high postnatal mortality, Mefolinate may be a good candidate drug for treatment of severe MTHFR deficiency	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + reduced acceptor	-	Homo sapiens	5-methyltetrahydrofolate + oxidized acceptor	-	?

Synonyms

Synonyms	Comment	Organism
methylenetetrahydrofolate reductase	-	Homo sapiens
MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)