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Literature summary for 1.5.1.20 extracted from

  • Pearson, A.G.M.; Turner, A.J.
    Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase (1975), Nature, 258, 173-174.
    View publication on PubMed
Search for more literature for 1.5.1.20

Inhibitors

Inhibitors Comment Organism Structure
2,4-dihydroxyphenylacetic acid at 0.01 M Sus scrofa
S-adenosylmethionine inhibition partially reversed by S-adenosylhomocysteine Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000 190000 gel filtration, single enzyme with methylenetetrahydrofolate reductase and dopamine methyltransferase activity Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + NADPH Sus scrofa initial enzyme in pathway leading to synthesis of S-adenosylmethionine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 a single enzyme with methylenetetrahydrofolate reductase and dopamine methyltransferase activity
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1
-
-
 Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + NADPH
-
 Sus scrofa 5-methyltetrahydrofolate + NADP+
-
 ?
5,10-methylenetetrahydrofolate + NADPH initial enzyme in pathway leading to synthesis of S-adenosylmethionine Sus scrofa ?
-
 ?