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Literature summary for 1.5.1.2 extracted from

  • Yin, F.; Huang, X.; Xuan, Y.
    Pyrroline-5-carboxylate reductase-2 promotes colorectal cancer progression via activating PI3K/AKT/mTOR pathway (2021), Dis. Markers, 2021, 9950663 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PYCR2 is highly expressed in colorectal cancer patients and high PYCR2 expression is associated with advanced stage, adenocarcinoma, nodal metastasis, and poor survival rate. PYCR2 knockdown reduces cell viability, proliferation, migration, and invasion and increases apoptosis. PYCR2 knockdown increases Bax, cleaved caspase-3, and cleaved PARP levels and decreases Bcl-2, MMP-2, MMP-9, p-PI3K, p-AKT, and p-mTOR levels in colorectal cancer cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96C36 isoform PYRC2
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Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
PYCR2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PYCR2 knockdown reduces cell viability, proliferation, migration, and invasion and increases apoptosis. PYCR2 knockdown increases Bax, cleaved caspase-3, and cleaved PARP levels and decreases Bcl-2, MMP-2, MMP-9, p-PI3K, p-AKT, and p-mTOR levels in colorectal cancer cells Homo sapiens