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Literature summary for 1.5.1.2 extracted from

  • Forlani, G.; Berlicki, L.; Duo, M.; Dziedziola, G.; Giberti, S.; Bertazzini, M.; Kafarski, P.
    Synthesis and evaluation of effective inhibitors of plant delta1-pyrroline-5-carboxylate reductase (2013), J. Agric. Food Chem., 61, 6792-6798.
    View publication on PubMed
Search for more literature for 1.5.1.2

Inhibitors

Inhibitors Comment Organism Structure
2,3-dichlorophenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(4-benzylphenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
3,5-dibromophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
3,5-difluorophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
3,5-dimethylphenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
3-carbamoylphenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
3-chlorophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
4-benzylphenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
4-benzylphenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
indan-5-ylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, anion exchange column chromatography, and gel filtration Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-5-carboxylate + NADH + H+
-
 Arabidopsis thaliana L-proline + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
DELTA1-pyrroline-5-carboxylate reductase
-
 Arabidopsis thaliana
P5C reductase
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Arabidopsis thaliana
NADPH
-
 Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.054
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-dibromophenylaminomethylenebisphosphonic acid
0.082
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
0.134
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.325
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 4-benzylphenylhydroxymethylenebisphosphonic acid
0.335
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.386
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
0.413
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
0.431
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
0.45
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.463
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
0.488
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
0.488
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(4-benzylphenylamino)ethylidenebisphosphonic acid
0.547
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3-carbamoylphenylaminomethylenebisphosphonic acid
0.684
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
0.719
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-difluorophenylaminomethylenebisphosphonic acid
0.763
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
0.852
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 4-benzylphenylaminomethylenebisphosphonic acid
0.97
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
1.187
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2,3-dichlorophenylhydroxymethylenebisphosphonic acid
1.245
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
1.409
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-dimethylphenylhydroxymethylenebisphosphonic acid
1.618
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3-chlorophenylaminomethylenebisphosphonic acid
1.639
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
1.887
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana indan-5-ylaminomethylenebisphosphonic acid
1.914
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
2.071
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid