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Literature summary for 1.5.1.2 extracted from

  • Pandhare, J.; Cooper, S.K.; Phang, J.M.
    Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms (2006), J. Biol. Chem., 281, 2044-2052.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
P53 POX is a p53-induced gene Homo sapiens
troglitazone is found to activate the POX promoter in colon cancer cells Homo sapiens

Application

Application Comment Organism
medicine proline oxidase can mediate apoptosis through generation of reactive oxygen species Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
a proline oxidase antisense vector is constructed by amplifying a part of the proline oxidase cDNA and cloning it in the mammalian expression vector pCI Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-proline + NAD(P)+ Homo sapiens
-
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCC-2998 cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HCT-15 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
KM-12 cell
-
Homo sapiens
-
LoVo cell
-
Homo sapiens
-
RKO cell
-
Homo sapiens
-
SW-620 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-proline + NAD(P)+
-
Homo sapiens 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
r

Synonyms

Synonyms Comment Organism
POX
-
Homo sapiens
proline oxidase
-
Homo sapiens
pyrroline-5-carboxylate reductase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
activity assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)H
-
Homo sapiens