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Literature summary for 1.5.1.2 extracted from

  • Strecker, H.J.
    DELTA1-pyrroline-5-carboxylate reductase (calf liver) (reduction of DELTA1-pyrroline-5-carboxylate to proline) (1971), Methods Enzymol., 17B, 258-261.
No PubMed abstract available
Search for more literature for 1.5.1.2

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Bos taurus
Ag+
-
 Bos taurus
ATP
-
 Bos taurus
Cd2+ 90% inhibition at 3.3 mM Bos taurus
Cu2+ 90% inhibition at 3.3 mM Bos taurus
Hg2+
-
 Bos taurus
hydroxylamine
-
 Bos taurus
Mn2+
-
 Bos taurus
NAD+
-
 Bos taurus
proline
-
 Bos taurus
thiazolidine-4-carboxylic acid
-
 Bos taurus
Zn2+
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calf
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.1
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Bos taurus L-proline + NAD(P)+
-
 ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7 7.4
-
 Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
6
-
 irreversible inactivation below Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH preferentially Bos taurus
NADPH
-
 Bos taurus