Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.15 extracted from

  • Gustafsson, R.; Jemth, A.S.; Gustafsson, N.M.; Faernegardh, K.; Loseva, O.; Wiita, E.; Bonagas, N.; Dahllund, L.; Llona-Minguez, S.; Haeggblad, M.; Henriksson, M.; Andersson, Y.; Homan, E.; Helleday, T.; Stenmark, P.
    Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitor (2017), Cancer Res., 77, 937-948 .
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme (MTHFD2) is highly relevant as an anticancer target Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the enzyme (MTHFD2) in complex with a substrate-based inhibitor and the enzyme cofactors NAD+ and inorganic phosphate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[1,5-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid i.e. LY345899 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P13995
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information upregulation and overexpression in cancer cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
MTHFD2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+-dependent enzyme Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation and overexpression in cancer cells up