Application | Comment | Organism |
---|---|---|
medicine | the enzyme (MTHFD2) is highly relevant as an anticancer target | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21(DE3) | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure of the enzyme (MTHFD2) in complex with a substrate-based inhibitor and the enzyme cofactors NAD+ and inorganic phosphate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[1,5-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid | i.e. LY345899 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13995 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | upregulation and overexpression in cancer cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MTHFD2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | NAD+-dependent enzyme | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | upregulation and overexpression in cancer cells | up |