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Literature summary for 1.5.1.15 extracted from
- The activities of the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells are kinetically independent (1988), J. Biol. Chem., 263, 4662-4667.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | requires phosphate anions for stability | Mus musculus |  |
General Stability
| General Stability | Organism |
|---|---|
| requires phosphate anions for stability | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-5,10-methenyl-tetrahydrofolate + NADH | Mus musculus | - |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
| L-5,10-methylenetetrahydrofolate + NAD+ | Mus musculus | - |
5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse, Ehrlich ascites tumor cells | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-5,10-methenyl-tetrahydrofolate + NADH | - |
Mus musculus | L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
| L-5,10-methylenetetrahydrofolate + NAD+ | - |
Mus musculus | 5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 34000, native bifunctional enzyme, associated with cyclohydrolase, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase | - |
Mus musculus |
| Mg2+/NAD-dependent methylenetetrahydrofolate dehydrogenase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mus musculus | |
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