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Literature summary for 1.5.1.11 extracted from

  • Storey, K.B.; Storey, J.M.
    Kinetic characterization of tissue-specific isozymes of octopine dehydrogenase from mantle muscle and brain of Sepia officinalis (1979), Eur. J. Biochem., 93, 545-552.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-Arg
-
Sepia officinalis
NAD+
-
Sepia officinalis
octopine substrate inhibition and product inhibition Sepia officinalis
pyruvate brain enzyme shows strong substrate inhibition, mantle muscle enzyme only slight inhibition Sepia officinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
NADH brain enzyme Sepia officinalis
0.03
-
NADH mantle muscle enzyme Sepia officinalis
0.09
-
octopine brain enzyme Sepia officinalis
0.11
-
NAD+ brain enzyme Sepia officinalis
0.25
-
pyruvate brain enzyme Sepia officinalis
0.25
-
pyruvate NAD+, mantle muscle enzyme Sepia officinalis
0.3
-
Arg pyruvate, mantle muscle enzyme Sepia officinalis
0.4
-
pyruvate Arg, brain enzyme Sepia officinalis
0.85
-
octopine octopine, mantle muscle enzyme Sepia officinalis
3.2
-
D-lysopine L-Arg, mantle muscle enzyme Sepia officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sepia officinalis the major role of the brain enzyme may be the oxidation of octopine ?
-
?
additional information Sepia officinalis mantle muscle enzyme appears geared for the rapid synthesis of octopine under conditions of muscular work ?
-
?

Organism

Organism UniProt Comment Textmining
Sepia officinalis
-
kinetically distinct tissue-specific isoenzymes
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sepia officinalis
-
mantle muscle
-
Sepia officinalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg + pyruvate + NADH
-
Sepia officinalis N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
?
L-Lys + pyruvate + NADH
-
Sepia officinalis Lysopine + NAD+ + H2O
-
?
additional information the major role of the brain enzyme may be the oxidation of octopine Sepia officinalis ?
-
?
additional information mantle muscle enzyme appears geared for the rapid synthesis of octopine under conditions of muscular work Sepia officinalis ?
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sepia officinalis