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Literature summary for 1.5.1.10 extracted from

  • Jones, E.E.; Broquist, H.P.
    Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase (1966), J. Biol. Chem., 241, 3430-3434.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
 NADP+
-
 Saccharomyces cerevisiae
0.92
-
 saccharopine
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-aminoadipate 6-semialdehyde + L-glutamate + NADPH Saccharomyces cerevisiae lysine biosynthesis N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 baker's yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminoadipate 6-semialdehyde + L-glutamate + NADPH
-
 Saccharomyces cerevisiae N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine r
2-aminoadipate 6-semialdehyde + L-glutamate + NADPH lysine biosynthesis Saccharomyces cerevisiae N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 saccharopine formation Saccharomyces cerevisiae
10
-
 saccharopine degradation Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
5.5 7.8 pH 5.5: about 45% of activity maximum, pH 7.8: about 35% of activity maximum Saccharomyces cerevisiae
8.3 10.3 about 50% of activity maximum at pH 8.3 and 10.3 Saccharomyces cerevisiae