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Literature summary for 1.5.1.1 extracted from

  • Hallen, A.; Jamie, J.F.; Cooper, A.J.
    Lysine metabolism in mammalian brain an update on the importance of recent discoveries (2013), Amino Acids, 45, 1249-1272 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Sus scrofa 5829
-
soluble
-
 Rattus norvegicus
-
-
soluble
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-piperideine-2-carboxylate + NAD(P)H + H+ Rattus norvegicus
-
 L-pipecolate + NAD(P)+
-
 r
1-piperideine-2-carboxylate + NAD(P)H + H+ Sus scrofa
-
 L-pipecolate + NAD(P)+
-
 r
1-pyrroline-2-carboxylate + NAD(P)H + H+ Rattus norvegicus
-
 L-proline + NAD(P)+
-
 r
1-pyrroline-2-carboxylate + NAD(P)H + H+ Sus scrofa
-
 L-proline + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from kidney Rattus norvegicus
native enzyme partially from kidney Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain high enzyme activity Rattus norvegicus
-
brain cortex
-
 Rattus norvegicus
-
cardiac muscle
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
kidney high enzyme activity Sus scrofa
-
spleen
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-piperideine-2-carboxylate + NAD(P)H + H+
-
 Rattus norvegicus L-pipecolate + NAD(P)+
-
 r
1-piperideine-2-carboxylate + NAD(P)H + H+
-
 Sus scrofa L-pipecolate + NAD(P)+
-
 r
1-pyrroline-2-carboxylate + NAD(P)H + H+
-
 Rattus norvegicus L-proline + NAD(P)+
-
 r
1-pyrroline-2-carboxylate + NAD(P)H + H+
-
 Sus scrofa L-proline + NAD(P)+
-
 r
additional information the enzyme from kidney shows no activity with DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ketimine reductase
-
 Rattus norvegicus
ketimine reductase
-
 Sus scrofa
P2C reductase
-
 Rattus norvegicus
P2C reductase
-
 Sus scrofa
P2C/Pyr2C reductase
-
 Rattus norvegicus
P2C/Pyr2C reductase
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
additional information NADH and NADPH are equally effective as cofactor for the enzyme purified from rat kidney Rattus norvegicus
additional information the enzyme purified from porcine kidney shows equal activity with NADPH and NADH Sus scrofa
NADH
-
 Rattus norvegicus
NADH
-
 Sus scrofa
NADPH
-
 Rattus norvegicus
NADPH
-
 Sus scrofa