BRENDA - Enzyme Database show
show all sequences of 1.4.99.6

D-Amino acid dehydrogenase from Helicobacter pylori NCTC 11637

Tanigawa, M.; Shinohara, T.; Saito, M.; Nishimura, K.; Hasegawa, Y.; Wakabayashi, S.; Ishizuka, M.; Nagata, Y.D; Amino Acids 38, 247-255 (2010)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Helicobacter pylori
Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxybenzoic acid
21.4% residual activity at 0.1 mM
Helicobacter pylori
Benzoate
2% residual activity at 0.1 mM
Helicobacter pylori
iodoacetamide
34.2% residual activity at 0.1 mM
Helicobacter pylori
iodoacetate
38.2% residual activity at 0.1 mM
Helicobacter pylori
additional information
not inhibited by EDTA
Helicobacter pylori
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0082
-
coenzyme Q1
in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
40.2
-
D-Pro
with Q1 as the electron acceptor, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
not influenced by Mg2+ and Ca+
Helicobacter pylori
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
44000
-
x * 44000, SDS-PAGE
Helicobacter pylori
46040
-
x * 46040, calculated from amino acid sequence
Helicobacter pylori
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-Pro + H2O + coenzyme Q1
Helicobacter pylori
D-Pro is the best substrate
?
-
-
?
D-Pro + H2O + coenzyme Q1
Helicobacter pylori NCTC 11637
D-Pro is the best substrate
?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Helicobacter pylori
A3KEZ1
-
-
Helicobacter pylori NCTC 11637
A3KEZ1
-
-
Purification (Commentary)
Commentary
Organism
DEAE-Toyopearl column chromatography
Helicobacter pylori
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.05
-
purified enzyme, with 20 mM D-Asp as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C; purified enzyme, with 20 mM D-Met as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C; purified enzyme, with 20 mM D-Val as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.06
-
purified enzyme, with 20 mM D-Glu as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.12
-
purified enzyme, with 20 mM L-Ala as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.22
-
purified enzyme, with 20 mM L-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.46
-
cell-free extract, with 20 mM D-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
1.25
-
purified enzyme, with 20 mM D-Ser as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
2.29
-
purified enzyme, with 20 mM D-Ala as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
6.22
-
purified enzyme, with 20 mM D-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
36.8% activity compared to D-Pro
695533
Helicobacter pylori
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
36.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Glu + H2O + oxidized 2,6-dichlorophenolindophenol
1.0% activity compared to D-Pro
695533
Helicobacter pylori
2-oxoglutarate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Glu + H2O + oxidized 2,6-dichlorophenolindophenol
1.0% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
2-oxoglutarate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Met + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Met + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Phe + H2O + oxidized 2,6-dichlorophenolindophenol
19.8% activity compared to D-Pro
695533
Helicobacter pylori
phenylpyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Pro + H2O + coenzyme Q1
D-Pro is the best substrate
695533
Helicobacter pylori
?
-
-
-
?
D-Pro + H2O + coenzyme Q1
D-Pro is the best substrate
695533
Helicobacter pylori NCTC 11637
?
-
-
-
?
D-Pro + H2O + oxidized 2,6-dichlorophenolindophenol
100% activity
695533
Helicobacter pylori
DELTA1-pyrroline-2-carboxylate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Ser + H2O + oxidized 2,6-dichlorophenolindophenol
6.7% activity compared to D-Pro
695533
Helicobacter pylori
3-hydroxy-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Val + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
2-oxoisopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
L-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
1.9% activity compared to D-Pro
695533
Helicobacter pylori
?
-
-
-
?
L-Pro + H2O + oxidized 2,6-dichlorophenolindophenol
3.5% activity compared to D-Pro
695533
Helicobacter pylori
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 44000, SDS-PAGE; x * 46040, calculated from amino acid sequence
Helicobacter pylori
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
-
Helicobacter pylori
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Helicobacter pylori
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Helicobacter pylori
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Helicobacter pylori
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Helicobacter pylori
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxybenzoic acid
21.4% residual activity at 0.1 mM
Helicobacter pylori
Benzoate
2% residual activity at 0.1 mM
Helicobacter pylori
iodoacetamide
34.2% residual activity at 0.1 mM
Helicobacter pylori
iodoacetate
38.2% residual activity at 0.1 mM
Helicobacter pylori
additional information
not inhibited by EDTA
Helicobacter pylori
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0082
-
coenzyme Q1
in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
40.2
-
D-Pro
with Q1 as the electron acceptor, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
not influenced by Mg2+ and Ca+
Helicobacter pylori
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
44000
-
x * 44000, SDS-PAGE
Helicobacter pylori
46040
-
x * 46040, calculated from amino acid sequence
Helicobacter pylori
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-Pro + H2O + coenzyme Q1
Helicobacter pylori
D-Pro is the best substrate
?
-
-
?
D-Pro + H2O + coenzyme Q1
Helicobacter pylori NCTC 11637
D-Pro is the best substrate
?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE-Toyopearl column chromatography
Helicobacter pylori
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.05
-
purified enzyme, with 20 mM D-Asp as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C; purified enzyme, with 20 mM D-Met as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C; purified enzyme, with 20 mM D-Val as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.06
-
purified enzyme, with 20 mM D-Glu as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.12
-
purified enzyme, with 20 mM L-Ala as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.22
-
purified enzyme, with 20 mM L-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
0.46
-
cell-free extract, with 20 mM D-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
1.25
-
purified enzyme, with 20 mM D-Ser as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
2.29
-
purified enzyme, with 20 mM D-Ala as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
6.22
-
purified enzyme, with 20 mM D-Pro as the substrate, in 50 mM sodium-phosphate buffer (pH 8.0), at 37°C
Helicobacter pylori
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
36.8% activity compared to D-Pro
695533
Helicobacter pylori
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
36.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Glu + H2O + oxidized 2,6-dichlorophenolindophenol
1.0% activity compared to D-Pro
695533
Helicobacter pylori
2-oxoglutarate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Glu + H2O + oxidized 2,6-dichlorophenolindophenol
1.0% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
2-oxoglutarate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Met + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Met + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori NCTC 11637
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Phe + H2O + oxidized 2,6-dichlorophenolindophenol
19.8% activity compared to D-Pro
695533
Helicobacter pylori
phenylpyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Pro + H2O + coenzyme Q1
D-Pro is the best substrate
695533
Helicobacter pylori
?
-
-
-
?
D-Pro + H2O + coenzyme Q1
D-Pro is the best substrate
695533
Helicobacter pylori NCTC 11637
?
-
-
-
?
D-Pro + H2O + oxidized 2,6-dichlorophenolindophenol
100% activity
695533
Helicobacter pylori
DELTA1-pyrroline-2-carboxylate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Ser + H2O + oxidized 2,6-dichlorophenolindophenol
6.7% activity compared to D-Pro
695533
Helicobacter pylori
3-hydroxy-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
D-Val + H2O + oxidized 2,6-dichlorophenolindophenol
0.8% activity compared to D-Pro
695533
Helicobacter pylori
2-oxoisopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
?
L-Ala + H2O + oxidized 2,6-dichlorophenolindophenol
1.9% activity compared to D-Pro
695533
Helicobacter pylori
?
-
-
-
?
L-Pro + H2O + oxidized 2,6-dichlorophenolindophenol
3.5% activity compared to D-Pro
695533
Helicobacter pylori
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 44000, SDS-PAGE; x * 46040, calculated from amino acid sequence
Helicobacter pylori
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
-
Helicobacter pylori
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Helicobacter pylori
Other publictions for EC 1.4.99.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740089
Ouedraogo
Importance of loop L1 dynamics ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM 22644
Biochemistry
56
2477-2487
2017
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4
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4
4
733215
Ball
Importance of glutamate 87 and ...
Pseudomonas aeruginosa
Arch. Biochem. Biophys.
568
56-63
2015
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2
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2
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5
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8
8
724092
Akita
Efficient synthesis of D-branc ...
Ureibacillus thermosphaericus, Ureibacillus thermosphaericus A1 (NBRC 108682)
Appl. Microbiol. Biotechnol.
98
1135-1143
2014
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1
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1
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6
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1
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1
1
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1
1
733354
Gannavaram
Mechanistic and computational ...
Pseudomonas aeruginosa
Biochemistry
53
6574-6583
2014
-
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1
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2
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2
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2
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2
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2
2
724690
Oliver
Impact of D-amino acid dehydro ...
Pseudomonas aeruginosa
Can. J. Microbiol.
59
598-603
2013
-
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1
-
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5
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1
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1
1
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726275
Bardaweel
E. coli histidine triad nucleo ...
Escherichia coli
PLoS ONE
6
e20897
2011
1
-
-
-
-
-
-
-
-
-
-
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6
-
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1
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1
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1
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-
-
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-
733330
Fu
Atomic-resolution structure of ...
Pseudomonas aeruginosa
Biochemistry
50
6292-6294
2011
-
-
1
1
-
-
-
-
-
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1
-
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734025
Yuan
Insights on the mechanism of a ...
Pseudomonas aeruginosa
J. Am. Chem. Soc.
133
18957-18965
2011
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1
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748083
He
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