BRENDA - Enzyme Database show
show all sequences of 1.4.99.6

D-Amino acid dehydrogenase (Pseudomonas fluorescens)

Tsukada, K.; Methods Enzymol. 17B, 623-624 (1971)
No PubMed abstract available

Data extracted from this reference:

General Stability
General Stability
Organism
very unstable
Pseudomonas fluorescens
Inhibitors
Inhibitors
Commentary
Organism
Structure
2,6-dichlorophenolindophenol
inhibition of the dichlorophenolindophenol-specific enzyme at high concentrations
Pseudomonas fluorescens
D-Amino acids
various D-amino acids competitively inhibit D-kynurenine deamination
Pseudomonas fluorescens
p-chloromercuribenzoic acid
90% inhibition of the methylene blue specific, 70% inhibition of the dichlorophenolindophenol specific enzyme at 0.5 mM
Pseudomonas fluorescens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.008
-
methylene blue
specific acceptor, cosubstrate: D-kynurenine
Pseudomonas fluorescens
0.07
-
2,6-dichlorophenolindophenol
specific acceptor, cosubstrate: D-kynurenine
Pseudomonas fluorescens
0.45
-
D-kynurenine
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
0.47
-
D-tryptophan
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas fluorescens
-
-
-
Purification (Commentary)
Commentary
Organism
near homogeneity, two enzymes with different acceptor specificities, fractionation and chromatography techniques
Pseudomonas fluorescens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
one methylene blue specific, one 2,6-dichlorophenolindophenol specific enzyme, the methylene blue specific enzyme is only detectable in D-tryptophan grown cells
Pseudomonas fluorescens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.113
-
methylene blue specific enzyme
Pseudomonas fluorescens
0.213
-
2,6-dichlorophenolindophenol specific enzyme
Pseudomonas fluorescens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-alanine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-alanine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
pyruvate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-asparagine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxosuccinamic acid + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-asparagine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxosuccinamic acid + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-cysteine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-mercapto-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-cystine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
? + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-histidine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-histidine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-isoleucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-methyl-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-isoleucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-methyl-2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-kynurenine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-(2-aminophenyl)-2,4-dioxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-kynurenine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
4-(2-aminophenyl)-2,4-dioxobutanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-leucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-methyl-2-oxopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-leucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
4-methyl-2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-methionine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-norleucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxohexanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-norleucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxohexanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-norvaline + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-phenylalanine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
phenylpyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-phenylalanine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
phenylpyruvate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-serine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-serine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-threonine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-threonine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxobutanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-tryptophan + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-indole-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-tryptophan + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-indole-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-tyrosine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-(4-hydroxyphenyl)-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-tyrosine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-(4-hydroxyphenyl)-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-valine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxoisopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-valine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxoisopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
8
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Pseudomonas fluorescens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Pseudomonas fluorescens
General Stability (protein specific)
General Stability
Organism
very unstable
Pseudomonas fluorescens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,6-dichlorophenolindophenol
inhibition of the dichlorophenolindophenol-specific enzyme at high concentrations
Pseudomonas fluorescens
D-Amino acids
various D-amino acids competitively inhibit D-kynurenine deamination
Pseudomonas fluorescens
p-chloromercuribenzoic acid
90% inhibition of the methylene blue specific, 70% inhibition of the dichlorophenolindophenol specific enzyme at 0.5 mM
Pseudomonas fluorescens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.008
-
methylene blue
specific acceptor, cosubstrate: D-kynurenine
Pseudomonas fluorescens
0.07
-
2,6-dichlorophenolindophenol
specific acceptor, cosubstrate: D-kynurenine
Pseudomonas fluorescens
0.45
-
D-kynurenine
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
0.47
-
D-tryptophan
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
Purification (Commentary) (protein specific)
Commentary
Organism
near homogeneity, two enzymes with different acceptor specificities, fractionation and chromatography techniques
Pseudomonas fluorescens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
one methylene blue specific, one 2,6-dichlorophenolindophenol specific enzyme, the methylene blue specific enzyme is only detectable in D-tryptophan grown cells
Pseudomonas fluorescens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.113
-
methylene blue specific enzyme
Pseudomonas fluorescens
0.213
-
2,6-dichlorophenolindophenol specific enzyme
Pseudomonas fluorescens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-alanine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
pyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-alanine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
pyruvate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-asparagine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxosuccinamic acid + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-asparagine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxosuccinamic acid + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-cysteine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-mercapto-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-cystine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
? + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-histidine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-histidine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-isoleucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-methyl-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-isoleucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-methyl-2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-kynurenine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-(2-aminophenyl)-2,4-dioxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-kynurenine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
4-(2-aminophenyl)-2,4-dioxobutanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-leucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-methyl-2-oxopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-leucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
4-methyl-2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-methionine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
4-methylsulfanyl-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-norleucine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxohexanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-norleucine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxohexanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-norvaline + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-phenylalanine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
phenylpyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-phenylalanine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
phenylpyruvate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-serine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-serine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-threonine + H2O + 2,6-dichlorophenolindophenol
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxobutanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-threonine + H2O + methylene blue
low activity
394974
Pseudomonas fluorescens
3-hydroxy-2-oxobutanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-tryptophan + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-indole-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-tryptophan + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-indole-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-tyrosine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
3-(4-hydroxyphenyl)-2-oxopropanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-tyrosine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
3-(4-hydroxyphenyl)-2-oxopropanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
D-valine + H2O + 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
2-oxoisopentanoate + NH3 + reduced 2,6-dichlorophenolindophenol
-
394974
Pseudomonas fluorescens
?
D-valine + H2O + methylene blue
-
394974
Pseudomonas fluorescens
2-oxoisopentanoate + NH3 + reduced methylene blue
-
394974
Pseudomonas fluorescens
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
8
both methylene blue and 2,6-dichlorophenolindophenol specific enzymes
Pseudomonas fluorescens
Other publictions for EC 1.4.99.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740089
Ouedraogo
Importance of loop L1 dynamics ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM 22644
Biochemistry
56
2477-2487
2017
-
-
1
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2
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3
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2
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4
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1
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2
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2
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4
-
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-
4
4
733215
Ball
Importance of glutamate 87 and ...
Pseudomonas aeruginosa
Arch. Biochem. Biophys.
568
56-63
2015
-
-
-
-
2
-
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2
-
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2
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4
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2
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2
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4
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5
-
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8
8
724092
Akita
Efficient synthesis of D-branc ...
Ureibacillus thermosphaericus, Ureibacillus thermosphaericus A1 (NBRC 108682)
Appl. Microbiol. Biotechnol.
98
1135-1143
2014
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
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1
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-
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6
-
1
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1
1
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2
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1
2
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1
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1
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6
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
733354
Gannavaram
Mechanistic and computational ...
Pseudomonas aeruginosa
Biochemistry
53
6574-6583
2014
-
-
1
-
2
-
-
2
-
-
-
-
-
2
-
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1
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2
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1
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2
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2
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1
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2
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2
2
724690
Oliver
Impact of D-amino acid dehydro ...
Pseudomonas aeruginosa
Can. J. Microbiol.
59
598-603
2013
-
-
1
-
-
-
-
-
-
-
-
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-
5
-
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1
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1
1
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-
726275
Bardaweel
E. coli histidine triad nucleo ...
Escherichia coli
PLoS ONE
6
e20897
2011
1
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-
-
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-
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6
-
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-
-
-
-
-
-
1
-
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-
-
-
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