Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.5 extracted from

  • Takeuchi, F.; Tsubouchi, R.; Shibata, Y.
    Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro (1985), Biochem. J., 227, 537-544.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
3-Hydroxyanthranilate 145% increase in pyridoxine 5-phosphate oxidase activity, 28% increase in pyridoxamine 5-phosphate oxidase activity Rattus norvegicus
3-hydroxykynurenine 125% increase in pyridoxine 5-phosphate oxidase activity, 20% increase in pyridoxamine 5-phosphate oxidase activity Rattus norvegicus
5-hydroxyindolacetate 125% increase in pyridoxine 5-phosphate oxidase activity, 9% increase in pyridoxamine 5-phosphate oxidase activity Rattus norvegicus
5-hydroxytryptamine 20% increase in pyridoxamine 5-phosphate oxidase activity Rattus norvegicus
tryptamine 27% increase in pyridoxamine 5-phosphate oxidase activity Rattus norvegicus
xanthurenate 21% increase in pyridoxine 5-phosphate oxidase activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by tryptophan metabolites Rattus norvegicus
pyridoxamine 5'-phosphate substrate inhibition above 0.0006 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00092
-
pyridoxine 5'-phosphate
-
Rattus norvegicus
0.01
-
pyridoxamine 5'-phosphate
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.138
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridoxamine 5'-phosphate + H2O + O2
-
Rattus norvegicus pyridoxal 5'-phosphate + NH3 + H2O2
-
?
pyridoxine 5'-phosphate + FMN
-
Rattus norvegicus pyridoxal 5'-phosphate + FMNH2
-
?