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Literature summary for 1.4.3.4 extracted from
- Kinetics, mechanism, and inhibition of monoamine oxidase (2018), J. Neural Transm., 125, 1659-1683 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-phenylcyclopropylamine | moderate isoenzyme selectivity; moderate isoenzyme selectivity | Homo sapiens |  |
| Azure Blue | - |
Homo sapiens | |
| cis-N-benzyl-2-methoxycyclopropylamine | high inhibitory action, exhibits a poor isozyme selectivity; high inhibitory action, exhibits a poor isozyme selectivity | Homo sapiens | |
| D-amphetamine | i.e. 1-phenyl-2-propanamine | Homo sapiens | |
| harmine | - |
Homo sapiens | |
| metamphetamine | i.e. N-methyl-1-phenyl-2-propanamine; i.e. N-methyl-1-phenyl-2-propanamine | Homo sapiens | |
| methylene blue | - |
Homo sapiens | |
| moclobemide | - |
Homo sapiens | |
| phentermine | i.e. 2-methyl-1-phenyl-2-propanamine; i.e. 2-methyl-1-phenyl-2-propanamine | Homo sapiens | |
| pioglitazone | - |
Homo sapiens | |
| safinamide | - |
Homo sapiens | |
| sembragiline | - |
Homo sapiens | |
| tetrindole | - |
Homo sapiens | |
| tranylcypromine | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P21397 | - |
- |
| Homo sapiens | P27338 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methyl-4-(1-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO-A | - |
Homo sapiens |
| MAO-B | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000026 | - |
Azure Blue | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000005 | - |
harmine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000009 | - |
tetrindole | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000027 | - |
methylene blue | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0038 | - |
tranylcypromine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0077 | - |
tranylcypromine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.011 | 0.2 | moclobemide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.015 | - |
D-amphetamine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.017 | - |
metamphetamine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.138 | - |
phentermine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.196 | - |
phentermine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.297 | - |
metamphetamine | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000006 | - |
pH and temperature not specified in the publication | Homo sapiens | sembragiline | |
| 0.00045 | - |
pH and temperature not specified in the publication | Homo sapiens | safinamide | |
| 0.0005 | - |
pH and temperature not specified in the publication | Homo sapiens | pioglitazone | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | monoamine oxidases catalyse the oxidation of neurotransmitter amines and a wide variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs. While inhibition of MAO activity in the periphery removes protection from biogenic amines and so is undesirable, inhibition in the brain gives vital antidepressant and behavioural advantages that make MAO a major pharmaceutical target for inhibitor design | Homo sapiens |
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