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Literature summary for 1.4.3.4 extracted from

  • Reis, J.; Manzella, N.; Cagide, F.; Mialet-Perez, J.; Uriarte, E.; Parini, A.; Borges, F.; Binda, C.
    Tight-binding inhibition of human monoamine oxidase B by chromone analogs a kinetic, crystallographic, and biological analysis (2018), J. Med. Chem., 61, 4203-4212 .
    View publication on PubMed
Search for more literature for 1.4.3.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-carboxamide tight-binding mechanism of inhibition Homo sapiens
N-(3'-chlorophenyl)-4-oxo-4H-chromene-3-carboxamide tight-binding mechanism of inhibition Homo sapiens
N-(3'-fluorophenyl)-4-oxo-4H-chromene-3-carboxamide tight-binding mechanism of inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
MAO-B
-
 Homo sapiens
monoamine oxidase B
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000017
-
 N-(3'-chlorophenyl)-4-oxo-4H-chromene-3-carboxamide pH 7.5, 25°C Homo sapiens
0.000031
-
 N-(3'-fluorophenyl)-4-oxo-4H-chromene-3-carboxamide pH 7.5, 25°C Homo sapiens
0.000055
-
 N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-carboxamide pH 7.5, 25°C Homo sapiens