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Literature summary for 1.4.3.4 extracted from
- Synthesis, characterization, monoamine oxidase inhibition, molecular docking and dynamic simulations of novel 2,1-benzothiazine-2,2-dioxide derivatives (2018), Bioorg. Chem., 80, 498-510 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| (4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | - |
Homo sapiens | |
| Clorgyline | - |
Homo sapiens |  |
| clorogyline | - |
Homo sapiens | |
| Deprenyl | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P21397 | - |
- |
| Homo sapiens | P27338 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO-A | - |
Homo sapiens |
| MAO-B | - |
Homo sapiens |
| monoamine oxidase A | - |
Homo sapiens |
| monoamine oxidase B | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | FAD-dependent oxidoreductase | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000128 | - |
Clorgyline | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000087 | - |
Deprenyl | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000034 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000054 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000058 | - |
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000062 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000062 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00006285 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000066 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00007142 | - |
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00008 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000126 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000131 | - |
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000138 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00014 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000154 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000222 | - |
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000284 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000293 | - |
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000306 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00036 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00038 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000453 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0005343 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000613 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000716 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0007371 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000951 | - |
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.001063 | - |
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.001356 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.001606 | - |
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0018622 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0019214 | - |
Deprenyl | pH and temperature not specified in the publication | Homo sapiens | |
| 0.004429 | - |
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.005886 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.006267 | - |
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.008543 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.011244 | - |
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0114 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.011429 | - |
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.011429 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.012657 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.021822 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.025244 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.026622 | - |
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.027267 | - |
clorogyline | pH and temperature not specified in the publication | Homo sapiens | |
| 0.030444 | - |
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens | |
| 0.033956 | - |
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000045 | - |
pH and temperature not specified in the publication | Homo sapiens | Clorgyline | |
| 0.0000196 | - |
pH and temperature not specified in the publication | Homo sapiens | Deprenyl | |
| 0.00012 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00013 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00014 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00014 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00015 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00018 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00022 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00025 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00031 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00044 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00046 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00049 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0005 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00054 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00064 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00066 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00102 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00107 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00126 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00133 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00138 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00161 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00187 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00214 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00258 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00305 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00372 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.00562 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0141 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0155 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0206 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0253 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0299 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0399 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0419 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0443 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0491 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0522 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0568 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0599 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.06135 | - |
pH and temperature not specified in the publication | Homo sapiens | clorogyline | |
| 0.06725 | - |
pH and temperature not specified in the publication | Homo sapiens | Deprenyl | |
| 0.0685 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 0.0764 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione | |
| 40 | - |
pH and temperature not specified in the publication | Homo sapiens | (4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione |
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Release 2023.1 (January 2023)
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