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Literature summary for 1.4.3.4 extracted from

  • Aldeco, M.; Arslan, B.K.; Edmondson, D.E.
    Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B (2011), Comp. Biochem. Physiol. B, 159, 78-83.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
8-(3-chlorostyryl)-caffeine
-
 Danio rerio
D-amphetamine
-
 Danio rerio
Harmane
-
 Danio rerio
methylene blue
-
 Danio rerio
additional information not inhibited by D-amphetamine, farnesol, safinamide, 1,4-diphenyl-1,3-butadiene, and 1,4-diphenyl-2-butene Danio rerio
pirlindole mesylate
-
 Danio rerio
tetrindole mesylate
-
 Danio rerio

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
 tyramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0555
-
 1-(4-methoxyphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.058
-
 kynuramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0678
-
 1-(4-methylphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.069
-
 serotonin at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.076
-
 4-carboxybenzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0822
-
 benzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.088
-
 dopamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.094
-
 1-(4-chlorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.103
-
 1-(4-bromophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.115
-
 1-[4-(trifluoromethyl)phenyl]methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.161
-
 1-(4-fluorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.185
-
 4-phenylbutylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dopamine + H2O + O2 Danio rerio
-
 (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
kynuramine + H2O + O2 Danio rerio
-
 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
serotonin + H2O + O2 Danio rerio
-
 (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
tyramine + H2O + O2 Danio rerio
-
 (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(4-bromophenyl)methanamine + H2O + O2
-
 Danio rerio 4-bromobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-chlorophenyl)methanamine + H2O + O2
-
 Danio rerio 4-chlorobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-fluorophenyl)methanamine + H2O + O2
-
 Danio rerio 4-fluorobenzaldehyde + NH3 + H2O2
-
 ?
1-(4-methoxyphenyl)methanamine + H2O + O2
-
 Danio rerio 4-methoxybenzaldehyde + NH3 + H2O2
-
 ?
1-(4-methylphenyl)methanamine + H2O + O2
-
 Danio rerio 4-methylbenzaldehyde + NH3 + H2O2
-
 ?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
-
 Danio rerio 4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
 ?
4-carboxybenzylamine + H2O + O2
-
 Danio rerio ?
-
 ?
4-phenylbutylamine + H2O + O2
-
 Danio rerio ?
-
 ?
benzylamine + H2O + O2
-
 Danio rerio benzaldehyde + NH3 + H2O2
-
 ?
dopamine + H2O + O2
-
 Danio rerio (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
kynuramine + H2O + O2
-
 Danio rerio 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
additional information 3-aminomethylpyridine is not a substrate Danio rerio ?
-
 ?
serotonin + H2O + O2
-
 Danio rerio (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
tyramine + H2O + O2
-
 Danio rerio (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO
-
 Danio rerio

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.08
-
 benzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.088
-
 4-carboxybenzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.12
-
 1-(4-methylphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.14
-
 1-(4-methoxyphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.25
-
 1-(4-fluorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.58
-
 1-(4-chlorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.67
-
 1-(4-bromophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.25
-
 kynuramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.57
-
 1-[4-(trifluoromethyl)phenyl]methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
2.07
-
 4-phenylbutylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
3.12
-
 serotonin at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
4.03
-
 dopamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
7.78
-
 tyramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Danio rerio

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000004
-
 methylene blue at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0024
-
 pirlindole mesylate at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0024
-
 8-(3-chlorostyryl)-caffeine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.013
-
 Harmane at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.0341
-
 tetrindole mesylate at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
0.038
-
 D-amphetamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio