Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)-hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(octan-2-ylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine | - |
Homo sapiens | |
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine | - |
Homo sapiens | |
brofaromine | inhibitor of MAO-A | Homo sapiens | |
Clorgyline | inhibitor of MAO-A | Homo sapiens | |
Iproniazide | inhibitor of MAO-A and MAO-B | Homo sapiens | |
isatin | inhibitor of MAO-B | Homo sapiens | |
isocarboxazide | inhibitor of MAO-A and MAO-B | Homo sapiens | |
lazabemide | inhibitor of MAO-B | Homo sapiens | |
moclobemide | inhibitor of MAO-A | Homo sapiens | |
additional information | synthesis and molecular modeling of selective monoamine oxidase inhibitors from a 2-thiazolylhydrazyne scaffold, structure-activity relationships, overview. No or poor activity against MAO-A with 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine, and 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine, and against MAO-B with 5, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine, and 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)-hydrazine | Homo sapiens | |
Pargyline | inhibitor of MAO-A and MAO-B | Homo sapiens | |
R-(-)-deprenyl | inhibitor of MAO-B | Homo sapiens | |
rasagiline | inhibitor of MAO-B | Homo sapiens | |
toloxatone | inhibitor of MAO-A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-tyramine + H2O + O2 | substrate for both hMAO-A and hMAO-B | Homo sapiens | 4-hydroxyphenylacetaldehyde + NH3 + H2O2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000122 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine | |
0.0000266 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine | |
0.0000295 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine | |
0.0000318 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine | |
0.0000355 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine | |
0.0000727 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine | |
0.000116 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine | |
0.000231 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine | |
0.000333 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine | |
0.000343 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)-hydrazine | |
0.000414 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine | |
0.000455 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine | |
0.000458 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine | |
0.00049 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine | |
0.000538 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine | |
0.00055 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine | |
0.000592 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine | |
0.000636 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine | |
0.000679 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine | |
0.000698 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine | |
0.000737 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine | |
0.000749 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine | |
0.000772 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine | |
0.0008 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine | |
0.000824 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine | |
0.000836 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine | |
0.000872 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine | |
0.000875 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)hydrazine | |
0.00106 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine | |
0.00114 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine | |
0.00115 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine | |
0.00131 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine | |
0.00138 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(octan-2-ylidene)hydrazine | |
0.00145 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine | |
0.00168 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine | |
0.00178 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine | |
0.00191 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine | |
0.00291 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine | |
0.0036 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine | |
0.0037 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine | |
0.00381 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine | |
0.00443 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine | |
0.00507 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine | |
0.00556 | - |
MAO A, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine | |
0.00672 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine | |
0.00678 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)hydrazine | |
0.00697 | - |
MAO B, pH 7.4, 37°C | Homo sapiens | 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine |