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Literature summary for 1.4.3.4 extracted from

  • Geldenhuys, W.J.; Darvesh, A.S.; Funk, M.O.; Van der Schyf, C.J.; Carroll, R.T.
    Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening (2010), Bioorg. Med. Chem. Lett., 20, 5295-5298.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
(5Z)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione L136468, binding mode, overview Homo sapiens
(5Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione A6355 Homo sapiens
(5Z)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione L136662 Homo sapiens
(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione AS605240, binding mode, overview Homo sapiens
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(3-hydroxyphenyl)acetamide 6164872 Homo sapiens
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-phenylacetamide 6163851 Homo sapiens
3-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid R598127 Homo sapiens
5-(4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl)-1,3-thiazolidine-2,4-dione i.e. rosiglitazone Homo sapiens
5-(4-[(1-methylcyclohexyl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione i.e. ciglitazone Homo sapiens
5-(4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione i.e. troglitazone Homo sapiens
5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)-1,3-thiazolidine-2,4-dione i.e. pioglitazone, docking of R-pioglitazone in the substrate cavity of MAO-B Homo sapiens
7-[(3-chlorophenyl)methoxy]-4-(methylaminomethyl)chromen-2-one
-
 Homo sapiens
[(5E)-2,4-dioxo-5-(phenylimino)-1,3-thiazolidin-3-yl]acetonitrile R598119 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
-
-

Synonyms

Synonyms Comment Organism
MAO-B
-
 Homo sapiens
monoamine oxidase B
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000048
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)-1,3-thiazolidine-2,4-dione
0.000082
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (5Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
0.000195
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (5Z)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
0.000225
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl)-1,3-thiazolidine-2,4-dione
0.000298
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(4-[(1-methylcyclohexyl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
0.000832
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
0.00207
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 7-[(3-chlorophenyl)methoxy]-4-(methylaminomethyl)chromen-2-one
0.00229
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens [(5E)-2,4-dioxo-5-(phenylimino)-1,3-thiazolidin-3-yl]acetonitrile
0.011
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(3-hydroxyphenyl)acetamide
0.013
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
0.022
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-phenylacetamide
0.027
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (5Z)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
0.056
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid