Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Harmaline | MAOI harmaline significantly reduces 5-MeO-DMT depletion and increases bufotenine formation in human hepatocytes | Homo sapiens | |
Harmaline | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | Mus musculus | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination | ? | - |
? | |
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | Homo sapiens | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
wild-type FVB/N and Tg-CYP2D6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination | Mus musculus | ? | - |
? | |
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination | Homo sapiens | ? | - |
? | |
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius | Mus musculus | ? | - |
? | |
5-methoxy-N,N-dimethyltryptamine + H2O + O2 | i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Mus musculus |
MAO-A | - |
Homo sapiens |
monoamine oxidase-A | - |
Mus musculus |
monoamine oxidase-A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination | Mus musculus |
physiological function | MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination. MAO-A-mediated deamination is the major metabolic pathway for 5-MeO-DMT | Homo sapiens |