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Literature summary for 1.4.3.4 extracted from
- Inhibitory effect of dehydroepiandrosterone on brain monoamine oxidase activity: in vivo and in vitro studies (2009), Life Sci., 85, 652-656.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clorgyline | - |
Rattus norvegicus |  |
| dehydroepiandrosterone | at 0.1 mM, inhibition of MAO-A by 44.2%; at 0.1 mM, inhibition of MAO-B by 61.2% | Rattus norvegicus | |
| additional information | no inhibhition of MAO-A by selegiline; no inhibition of MAO-B by clorgyline | Rattus norvegicus | |
| selegiline | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P19643 | male Wistar rats | - |
| Rattus norvegicus | P21396 | male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| corpus striatum | - |
Rattus norvegicus | - |
| nucleus accumbens | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activities of MAO isozymes in brain regions in presence and absence of dehydroepiandrosterone | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kynuramine + H2O + O2 | - |
Rattus norvegicus | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO-A | - |
Rattus norvegicus |
| MAO-B | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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