Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | the irreversible MAO-A inhibitor shows anti-oncogenic and pro-differentiation effects on high grade prostate cancer cells, inhibition of MAO-A might restore differentiation and reverse the aggressive behavior of high grade prostate cancer cells, overview. The inhibitor has significant gene regulatory effects on the beta-catenin and ERBB2 pathways in vivo, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-hydroxytryptamine + H2O + O2 | Homo sapiens | - |
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
additional information | Homo sapiens | MAO-A degrades monoamines including neurotransmitters | ? | - |
? | |
norepinephrine + H2O + O2 | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate gland | is highly expressed in basal cells of the normal prostatic epithelium and in poorly differentiated, aggressive prostate cancer | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-hydroxytryptamine + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
additional information | MAO-A degrades monoamines including neurotransmitters | Homo sapiens | ? | - |
? | |
norepinephrine + H2O + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |