Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.4 extracted from

  • Zhao, H.; Flamand, V.; Peehl, D.M.
    Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells (2009), BMC Med. Genomics, 2, 55.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Clorgyline the irreversible MAO-A inhibitor shows anti-oncogenic and pro-differentiation effects on high grade prostate cancer cells, inhibition of MAO-A might restore differentiation and reverse the aggressive behavior of high grade prostate cancer cells, overview. The inhibitor has significant gene regulatory effects on the beta-catenin and ERBB2 pathways in vivo, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-hydroxytryptamine + H2O + O2 Homo sapiens
-
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
additional information Homo sapiens MAO-A degrades monoamines including neurotransmitters ?
-
?
norepinephrine + H2O + O2 Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland is highly expressed in basal cells of the normal prostatic epithelium and in poorly differentiated, aggressive prostate cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxytryptamine + H2O + O2
-
Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
additional information MAO-A degrades monoamines including neurotransmitters Homo sapiens ?
-
?
norepinephrine + H2O + O2
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
monoamine oxidase A
-
Homo sapiens