Crystallization (Comment) | Organism |
---|---|
crystal structures of human MAO B in complex with the three inhibitors (safinamide, 7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin or 7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin) reveal that they all bind noncovalently to the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin | binds noncovalently to MAO B, occupying both the entrance and the substrate cavities | Homo sapiens | |
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin | binds noncovalently to MAO B, occupying both the entrance and the substrate cavities | Homo sapiens | |
safinamide | binds noncovalently to MAO B, occupying both the entrance and the substrate cavities | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | - |
- |
Homo sapiens | P27338 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MAO A | - |
Homo sapiens |
MAO B | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |
monoamine oxidase B | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin | 25°C, pH 7.5 | Homo sapiens | |
0.0004 | - |
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin | 25°C, pH 7.5 | Homo sapiens | |
0.00045 | - |
safinamide | 25°C, pH 7.5 | Homo sapiens | |
0.011 | - |
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin | 25°C, pH 7.5 | Homo sapiens | |
0.0157 | - |
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin | 25°C, pH 7.5 | Homo sapiens | |
0.365 | - |
safinamide | 25°C, pH 7.5 | Homo sapiens |