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Literature summary for 1.4.3.4 extracted from

  • Coatrieux, C.; Sanson, M.; Negre-Salvayre, A.; Parini, A.; Hannun, Y.; Itohara, S.; Salvayre, R.; Auge, N.
    MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway (2007), Free Radic. Biol. Med., 43, 80-89.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tyramine + H2O + O2 Oryctolagus cuniculus H2O2-generated during tyramine oxidation by MAO-A triggers a stress-induced mitogenic signaling via the MMP2/sphingolipid pathway, which could participate in excessive remodeling and alteration of the vascular wall (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
femoral muscle
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Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tyramine + H2O + O2
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Oryctolagus cuniculus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
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?
tyramine + H2O + O2 H2O2-generated during tyramine oxidation by MAO-A triggers a stress-induced mitogenic signaling via the MMP2/sphingolipid pathway, which could participate in excessive remodeling and alteration of the vascular wall Oryctolagus cuniculus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
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?

Synonyms

Synonyms Comment Organism
MAO-A
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Oryctolagus cuniculus
monoamine oxidase A
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Oryctolagus cuniculus