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Literature summary for 1.4.3.4 extracted from

  • Ogunrombi, M.O.; Malan, S.F.; Terreblanche, G.; Castagnoli, N.; Bergh, J.J.; Petzer, J.P.
    Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles (2008), Bioorg. Med. Chem., 16, 2463-2472.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-3-(3-methylphenyl)-1H-pyrrole
-
Papio hamadryas
1-methyl-3-(4-methylphenyl)-1H-pyrrole
-
Papio hamadryas
1-methyl-3-phenyl-1H-pyrrole
-
Papio hamadryas
1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrrole
-
Papio hamadryas
3-(3-bromophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(3-chlorophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(3-fluorophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(3-methoxyphenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(3-tert-butylphenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(4-bromophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(4-chlorophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(4-fluorophenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas
3-(4-methoxyphenyl)-1-methyl-1H-pyrrole
-
Papio hamadryas

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Papio hamadryas 5739
-

Organism

Organism UniProt Comment Textmining
Papio hamadryas
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Papio hamadryas
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + O2
-
Papio hamadryas 1-methyl-4-phenyl-2,3-dihydropyridinium + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-B
-
Papio hamadryas
monoamine oxidase B
-
Papio hamadryas

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0013
-
1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.00655
-
3-(3-tert-butylphenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.00665
-
3-(4-bromophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0143
-
3-(3-bromophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0184
-
3-(4-chlorophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0209
-
3-(3-chlorophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0225
-
1-methyl-3-(4-methylphenyl)-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.031
-
3-(4-fluorophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0365
-
3-(4-methoxyphenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0389
-
3-(3-fluorophenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.0417
-
3-(3-methoxyphenyl)-1-methyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.056
-
1-methyl-3-(3-methylphenyl)-1H-pyrrole pH 7.4, 37°C Papio hamadryas
0.118
-
1-methyl-3-phenyl-1H-pyrrole pH 7.4, 37°C Papio hamadryas