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Literature summary for 1.4.3.4 extracted from

  • Hubalek, F.; Binda, C.; Khalil, A.; Li, M.; Mattevi, A.; Castagnoli, N.; Edmondson, D.E.
    Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors (2005), J. Biol. Chem., 280, 15761-15766.
    View publication on PubMed
Search for more literature for 1.4.3.4

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor diffusion method, crystal structures of MAO B in complex with trans,trans-farnesol and that of the I199F MAO B mutant protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,4-diphenyl-2-butene monoamine oxidase B Equus caballus
1,4-diphenyl-2-butene monoamine oxidase B Homo sapiens
1,4-diphenyl-2-butene monoamine oxidase B Rattus norvegicus
8-(3-chlorostyryl)caffeine monoamine oxidase B Equus caballus
8-(3-chlorostyryl)caffeine monoamine oxidase B Homo sapiens
8-(3-chlorostyryl)caffeine monoamine oxidase B Mus musculus
8-(3-chlorostyryl)caffeine monoamine oxidase B Rattus norvegicus
isatin
-
 Bos taurus
isatin monoamine oxidase A; monoamine oxidase B Homo sapiens
additional information no inhibition of monoamine oxidase B: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene Bos taurus
additional information no inhibition of monoamine oxidase A: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene Homo sapiens
additional information no inhibition of monoamine oxidase B: isatin, trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene Ovis aries
trans,trans-farnesol monoamine oxidase B Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus P56560
-
-
Equus caballus
-
-
-
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-
Mus musculus Q8BW75
-
-
Ovis aries
-
-
-
Rattus norvegicus P19643
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Equus caballus
-
liver
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzylamine + H2O + O2 monoamine oxidase B Ovis aries benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2 monoamine oxidase B Equus caballus benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2 monoamine oxidase B Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2 monoamine oxidase B Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2 monoamine oxidase B Mus musculus benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2 monoamine oxidase B Bos taurus benzaldehyde + NH3 + H2O2
-
 ?
kynuramine + H2O + O2 monoamine oxidase A Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO A
-
 Homo sapiens
MAO B
-
 Ovis aries
MAO B
-
 Equus caballus
MAO B
-
 Homo sapiens
MAO B
-
 Rattus norvegicus
MAO B
-
 Mus musculus
MAO B
-
 Bos taurus
monoamine oxidase A
-
 Homo sapiens
monoamine oxidase B
-
 Ovis aries
monoamine oxidase B
-
 Equus caballus
monoamine oxidase B
-
 Homo sapiens
monoamine oxidase B
-
 Rattus norvegicus
monoamine oxidase B
-
 Mus musculus
monoamine oxidase B
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 8-(3-chlorostyryl)caffeine monoamine oxidase B Homo sapiens
0.0002
-
 8-(3-chlorostyryl)caffeine monoamine oxidase B Mus musculus
0.0007
-
 1,4-diphenyl-2-butene monoamine oxidase B Homo sapiens
0.0011
-
 8-(3-chlorostyryl)caffeine monoamine oxidase B Rattus norvegicus
0.0014
-
 8-(3-chlorostyryl)caffeine monoamine oxidase B Equus caballus
0.0023
-
 trans,trans-farnesol monoamine oxidase B Homo sapiens
0.003
-
 isatin monoamine oxidase B Homo sapiens
0.006
-
 isatin monoamine oxidase B Bos taurus
0.006
-
 1,4-diphenyl-2-butene monoamine oxidase B Rattus norvegicus
0.0083
-
 1,4-diphenyl-2-butene monoamine oxidase B Equus caballus
0.015
-
 isatin monoamine oxidase A Homo sapiens