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Literature summary for 1.4.3.4 extracted from

  • Chimenti, F.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Carradori, S.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.
    Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of N,N-bis[2-oxo-2H-benzopyran]-3-carboxamides (2006), Bioorg. Med. Chem. Lett., 16, 4135-4140.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes; both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes Homo sapiens
N,N'-(1R,2S)-cyclohexane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
Bos taurus
N,N'-1,2-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
Bos taurus
N,N'-1,4-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
Bos taurus
N,N'-butane-1,4-diylbis(2-oxo-2H-chromene-3-carboxamide) potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B Bos taurus
N,N'-butane-1,4-diylbis(7-methoxy-2-oxo-2H-chromene-3-carboxamide)
-
Bos taurus
N,N'-ethane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
Bos taurus
N,N'-hexane-1,6-diylbis(2-oxo-2H-chromene-3-carboxamide) potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus P21398
-
-
Bos taurus P56560
-
-
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO A
-
Homo sapiens
MAO A
-
Bos taurus
MAO B
-
Homo sapiens
MAO B
-
Bos taurus