Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae YSA-1C | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
C406A | MAO-A, Km for serotonin and tyramine not altered | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | - |
Rattus norvegicus | |
Pargyline | irreversible inhibitor | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km of wild-type MAO-A and B and of their chimera | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Storage Stability | Organism |
---|---|
30°C, 8 h, 30% of initial activity of Ala-mutated enzyme, in the presence of 0.005 mM FAD 70% of activity | Rattus norvegicus |
30°C, 8 h, no decrease in activity of wild-type enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
RCH2NH2 + H2O + O2 | - |
Rattus norvegicus | RCHO + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | - |
Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + H2O + O2 | - |
Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | FAD is covalent linkage at Cys406 in MAO-A and is not essentiell for the catalytically activity | Rattus norvegicus |