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Literature summary for 1.4.3.4 extracted from

  • Hiro, I.; Tsugeno, Y.; Hirashiki, I.; Ogata, F.; Ito, A.
    Characterization of rat monoamine oxidase A with noncovalently-bound FAD expressed in yeast cells (1996), J. Biochem., 120, 759-765.
    View publication on PubMed
Search for more literature for 1.4.3.4

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae YSA-1C Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C406A MAO-A, Km for serotonin and tyramine not altered Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Clorgyline
-
 Rattus norvegicus
Pargyline irreversible inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km of wild-type MAO-A and B and of their chimera Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Storage Stability

Storage Stability Organism
30°C, 8 h, 30% of initial activity of Ala-mutated enzyme, in the presence of 0.005 mM FAD 70% of activity Rattus norvegicus
30°C, 8 h, no decrease in activity of wild-type enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RCH2NH2 + H2O + O2
-
 Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
serotonin + H2O + O2
-
 Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
flavin FAD is covalent linkage at Cys406 in MAO-A and is not essentiell for the catalytically activity Rattus norvegicus