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Literature summary for 1.4.3.4 extracted from
- The kinetic mechanisms of monoamine oxidases A and B (1991), Biochem. Soc. Trans., 19, 219-223.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amphetamine | - |
Bos taurus |  |
| amphetamine | - |
Homo sapiens | |
| D-amphetamine | - |
Bos taurus | |
| D-amphetamine | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | - |
Bos taurus | |
| 0.04 | - |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | MAO-A | Homo sapiens | |
| 0.11 | - |
kynuramine | MAO-A | Homo sapiens | |
| 0.19 | 0.25 | Phenylethylamine | MAO-B | Bos taurus | |
| 0.48 | 0.51 | benzylamine | MAO-B | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 | mechanism of monoamine oxidase A and B | Homo sapiens | |
| RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 | mechanism of monoamine oxidase A and B | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2 | - |
Bos taurus | ? | - |
? | |
| 2-phenylethylamine + H2O + O2 | - |
Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| 2-phenylethylamine + H2O + O2 | - |
Bos taurus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | - |
Bos taurus | benzaldehyde + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Bos taurus | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | - |
Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | - |
Bos taurus | RCHO + NH3 + H2O2 | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.16 | - |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | MAO-A | Homo sapiens | |
| 1.9 | - |
kynuramine | MAO-A | Homo sapiens | |
| 18.2 | 20.8 | Phenylethylamine | MAO-B | Bos taurus | |
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