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Literature summary for 1.4.3.4 extracted from
- Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A (2001), Biochemistry, 40, 14839-14846.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Saccharomyces cerevisiae | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y407F | Km for kynuramine not altered, higher Km for benzylamine analogue | Homo sapiens |
| Y444F | mutation alters the substrate specificity, that depends on the size of the aromatic ring and on the length of the alkyl side chain of various substrate analogues | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amphetamine | - |
Homo sapiens |  |
| Clorgyline | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | comparison of MAO-A mutants using kynuramine, benzylamine and para-substituted benzylamine analogues as substrates | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-phenylethylamine + H2O + O2 | - |
Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | analogs | Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
| dopamine + H2O + O2 | - |
Homo sapiens | (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | - |
Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | MAO is a novel type of disulfide oxidoreductase | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | turnover number of MAO-A mutants | Homo sapiens |
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Release 2023.1 (January 2023)
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