Protein Variants | Comment | Organism |
---|---|---|
D481N | homozygous Grin1D481N mutant mice with reduced NMDA-NR1 glycine affinity exhibit an altered anxiety-like behavior. Deficient DAO activity also reverses the anxiolytic effects of diminished NMDAR function in mice carrying both the homozygous Grin1D481N and Dao1G181R mutation, phenotypes, overview | Mus musculus |
G181R | homozygous Dao1G181R mutant mice that lack function of the D-serine catabolic enzyme DAO display an elevation in anxiety, homozygous Grin1D481N mutant mice with reduced NMDA-NR1 glycine affinity exhibit also an altered anxiety-like behavior. Deficient DAO activity also reverses the anxiolytic effects of diminished NMDAR function in mice carrying both the homozygous Grin1D481N and Dao1G181R mutation, phenotypes, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | Mus musculus | physiological effects of D-serine, overview | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Mus musculus C57/BL6J | physiological effects of D-serine, overview | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | - |
Mus musculus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | physiological effects of D-serine, overview | Mus musculus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Mus musculus C57/BL6J | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | physiological effects of D-serine, overview | Mus musculus C57/BL6J | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Mus musculus |