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Literature summary for 1.4.3.22 extracted from

  • Elmore, B.O.; Bollinger, J.A.; Dooley, D.M.
    Human kidney diamine oxidase: heterologous expression, purification, and characterization (2002), J. Biol. Inorg. Chem., 7, 565-579.
    View publication on PubMed
Search for more literature for 1.4.3.22

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed as a secreted enzyme under the control of a metallothionein promoter in Drosophila S2 cell culture Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0028
-
 histamine pH 7.2, 37°C Homo sapiens
0.0034
-
 1-Methylhistamine pH 7.2, 37°C Homo sapiens
0.02
-
 putrescine pH 7.2, 37°C Homo sapiens
0.03
-
 cadaverine pH 7.2, 37°C Homo sapiens
0.11
-
 p-dimethylaminomethylbenzylamine pH 7.2, 37°C Homo sapiens
0.13
-
 1,3-diaminopropane pH 7.2, 37°C Homo sapiens
0.15
-
 1,6-diaminohexane pH 7.2, 37°C Homo sapiens
0.63
-
 ethylenediamine pH 7.2, 37°C Homo sapiens
1.1
-
 spermidine pH 7.2, 37°C Homo sapiens
2.8
-
 L-Lysine methyl ester pH 7.2, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ tightly bound, proposed to occupy a second metal-binding site Homo sapiens
copper 1.5 mol per mol of dimer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 20-26% glycosylation per weight Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon ascending, descending and transverse Homo sapiens
-
duodenum
-
 Homo sapiens
-
ileocecum
-
 Homo sapiens
-
ileum
-
 Homo sapiens
-
jejunum
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
rectum
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
vermiform appendix
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3-diaminopropane + H2O + O2
-
 Homo sapiens 3-aminopropanal + NH3 + H2O2
-
 ?
1,6-diaminohexane + H2O + O2
-
 Homo sapiens 6-aminohexanal + NH3 + H2O2
-
 ?
1-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
cadaverine + H2O + O2
-
 Homo sapiens ?
-
 ?
ethylenediamine + H2O + O2
-
 Homo sapiens ?
-
 ?
histamine + H2O + O2
-
 Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
L-lysine methyl ester + H2O + O2
-
 Homo sapiens ?
-
 ?
p-dimethylaminomethylbenzylamine + H2O + O2
-
 Homo sapiens ?
-
 ?
putrescine + H2O + O2
-
 Homo sapiens ?
-
 ?
spermidine + H2O + O2
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6180
-
 1-Methylhistamine pH 7.2, 37°C Homo sapiens
7560
-
 ethylenediamine pH 7.2, 37°C Homo sapiens
8340
-
 histamine pH 7.2, 37°C Homo sapiens
11220
-
 spermidine pH 7.2, 37°C Homo sapiens
17580
-
 1,6-diaminohexane pH 7.2, 37°C Homo sapiens
20700
-
 L-Lysine methyl ester pH 7.2, 37°C Homo sapiens
27180
-
 cadaverine pH 7.2, 37°C Homo sapiens
28500
-
 putrescine pH 7.2, 37°C Homo sapiens
29220
-
 1,3-diaminopropane pH 7.2, 37°C Homo sapiens
32880
-
 p-dimethylaminomethylbenzylamine pH 7.2, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.2 8.2 pH 6.2: about 75% of maximal activity, pH 8.2: about 60% of maximal activity Homo sapiens

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalaninequinone 1.1 mol per mol of dimer Homo sapiens