Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.21 extracted from

  • Elovaara, H.; Huusko, T.; Maksimow, M.; Elima, K.; Yegutkin, G.G.; Skurnik, M.; Dobrindt, U.; Siitonen, A.; McPherson, M.J.; Salmi, M.; Jalkanen, S.
    Primary amine oxidase of Escherichia coli is a metabolic enzyme that can use a human leukocyte molecule as a substrate (2015), PLoS ONE, 10, e0142367 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
amikacin about 60% residual activity at 1 mM Escherichia coli
BTT-2052
-
Escherichia coli
kanamycin about 70% residual activity at 1 mM Escherichia coli
additional information not inhibited by gentamycin Escherichia coli
Semicarbazide
-
Escherichia coli
sisomycin about 45% residual activity at 1 mM Escherichia coli
tobramycin about 40% residual activity at 1 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isoamylamine + H2O + O2
-
Escherichia coli isoamylaldehyde + NH3 + H2O2
-
?
additional information the enzyme can use human granulocytes as a substrate Escherichia coli ?
-
?
phenylethylamine + H2O + O2
-
Escherichia coli phenylacetaldehyde + NH3 + H2O2
-
?
propylamine + H2O + O2
-
Escherichia coli propanal + NH3 + H2O2
-
?
tryptamine + H2O + O2
-
Escherichia coli (1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
tyramine + H2O + O2
-
Escherichia coli 4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
CAO
-
Escherichia coli
copper-containing amine oxidase
-
Escherichia coli
PrAO
-
Escherichia coli
tynA
-
Escherichia coli
tyramine oxidase, copper-requiring
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00024
-
at pH 7.4 and 30°C Escherichia coli BTT-2052
0.0007
-
at pH 7.4 and 30°C Escherichia coli Semicarbazide
0.8
-
at pH 7.4 and 30°C Escherichia coli tobramycin
1
-
at pH 7.4 and 30°C Escherichia coli amikacin
3.8
-
at pH 7.4 and 30°C Escherichia coli kanamycin