Literature summary for 1.4.3.2 extracted from

Bhattacharjee, P.; Bera, I.; Chakraborty, S.; Ghoshal, N.; Bhattacharyya, D.
Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase (2017), Toxicon, 138, 1-17 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-chloro-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid	derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines	Daboia russelii
6-hydroxy-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid	derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines	Daboia russelii
aristolochic acid	reversible, mixed inhibition	Daboia russelii

Organism

Organism	UniProt	Comment	Textmining
Daboia russelii	G8XQX1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Daboia russelii	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-leucine + H2O + O2	-	Daboia russelii	4-methyl-2-oxo-pentanoate + NH3 + H2O2	-	?
L-phenylalanine + H2O + O2	-	Daboia russelii	phenylpyruvate + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
LAAO	-	Daboia russelii

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Release 2023.1 (January 2023)