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Literature summary for 1.4.3.2 extracted from

  • Deolindo, P.; Teixeira-Ferreira, A.S.; DaMatta, R.A.; Alves, E.W.
    L-amino acid oxidase activity present in fractions of Bothrops jararaca venom is responsible for the induction of programmed cell death in Trypanosoma cruzi (2010), Toxicon, 56, 944-955.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Bothrops jararaca
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-leucine + H2O + O2 Bothrops jararaca
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
additional information Bothrops jararaca Bothrops jararaca venom induces programmed cell death in epimastigotes of Trypanosoma cruzi due to its L-AAO activity, L-AAO activity induces parasites cytoplasmic retraction, mitochondrial swelling and DNA fragmentation, overview. L-AAO produces H2O2, which is highly toxic ?
-
?

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native extracellular enzyme from venom by gel filtration and anion exchange chromatography Bothrops jararaca

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops jararaca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine + H2O + O2
-
Bothrops jararaca 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
additional information Bothrops jararaca venom induces programmed cell death in epimastigotes of Trypanosoma cruzi due to its L-AAO activity, L-AAO activity induces parasites cytoplasmic retraction, mitochondrial swelling and DNA fragmentation, overview. L-AAO produces H2O2, which is highly toxic Bothrops jararaca ?
-
?

Synonyms

Synonyms Comment Organism
L-AAO
-
Bothrops jararaca

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Bothrops jararaca

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Bothrops jararaca

Cofactor

Cofactor Comment Organism Structure
FAD
-
Bothrops jararaca