Application | Comment | Organism |
---|---|---|
medicine | LAAO does not induce platelet aggregation, but it has potent inhibitory activity on platelet aggregation induced by ADP and U46619. It shows no effect on platelet aggregation induced by thrombin, mucetin, ristocetin and stejnulxin | Ophiophagus hannah |
Cloned (Comment) | Organism |
---|---|
- |
Bungarus fasciatus |
- |
Bungarus multicinctus |
- |
Naja atra |
into pGEM-T vector | Ophiophagus hannah |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
L-methionine | - |
Ophiophagus hannah | |
2.2 | - |
L-leucine | - |
Ophiophagus hannah | |
2.3 | - |
L-histidine | - |
Ophiophagus hannah | |
2.6 | - |
L-lysine | - |
Ophiophagus hannah | |
2.9 | - |
L-isoleucine | - |
Ophiophagus hannah |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53686 | - |
1 * 64000, SDS-PAGE under non-reducing conditions, 1 * 67000, SDS-PAGE under reducing conditions, 1 * 53686, sequence analysis | Ophiophagus hannah |
64000 | - |
1 * 64000, SDS-PAGE under non-reducing conditions, 1 * 67000, SDS-PAGE under reducing conditions, 1 * 53686, sequence analysis | Ophiophagus hannah |
67000 | - |
1 * 64000, SDS-PAGE under non-reducing conditions, 1 * 67000, SDS-PAGE under reducing conditions, 1 * 53686, sequence analysis | Ophiophagus hannah |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bungarus fasciatus | A8QL52 | - |
- |
Bungarus multicinctus | A8QL51 | - |
- |
Naja atra | A8QL58 | - |
- |
Ophiophagus hannah | P81383 | - |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration, ion-exchange and heparin chromatography, to homogeneity | Ophiophagus hannah |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Ophiophagus hannah | - |
venom | - |
Bungarus fasciatus | - |
venom | - |
Bungarus multicinctus | - |
venom | - |
Naja atra | - |
venom gland | - |
Ophiophagus hannah | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine + H2O + O2 | - |
Ophiophagus hannah | 3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2 | - |
? | |
L-isoleucine + H2O + O2 | - |
Ophiophagus hannah | 3-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
L-leucine + H2O + O2 | - |
Ophiophagus hannah | 4-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
L-lysine + H2O + O2 | - |
Ophiophagus hannah | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
L-methionine + H2O + O2 | - |
Ophiophagus hannah | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 64000, SDS-PAGE under non-reducing conditions, 1 * 67000, SDS-PAGE under reducing conditions, 1 * 53686, sequence analysis | Ophiophagus hannah |
Synonyms | Comment | Organism |
---|---|---|
LAAO | - |
Ophiophagus hannah |
LAAO | - |
Bungarus fasciatus |
LAAO | - |
Bungarus multicinctus |
LAAO | - |
Naja atra |