BRENDA - Enzyme Database show
show all sequences of 1.4.3.2

A new bacterial L-amino acid oxidase with a broad substrate specificity: purification and characterization

Geueke, B.; Hummel, W.; Enzyme Microb. Technol. 31, 77-87 (2002)
No PubMed abstract available

Data extracted from this reference:

General Stability
General Stability
Organism
freezing at -18°C without addition of glycerol inactivates the enzyme
Rhodococcus opacus
stability of the enzyme can be increased by storage or incubation of the enzyme in glycine/NaOH buffer
Rhodococcus opacus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Gly
competitive inhibition of reaction with L-Ala, does not reduce activity when 10 mM L-Phe is used as substrate
Rhodococcus opacus
glycine
activity strongly decreased in glycine/NaOH-buffer, competitive inhibition, no inhibition, when 10 mM L-phenylanalnine is used as substrate
Rhodococcus opacus
L-arginine
; pH 7.6, 30°C
Rhodococcus opacus
L-citrulline
; pH 7.6, 30°C
Rhodococcus opacus
L-leucine
; pH 7.6, 30°C
Rhodococcus opacus
L-lysine
; pH 7.6, 30°C
Rhodococcus opacus
L-methionine
; pH 7.6, 30°C
Rhodococcus opacus
L-norleucine
; pH 7.6, 30°C
Rhodococcus opacus
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
L-phenylalanine
; pH 7.6, 30°C
Rhodococcus opacus
L-serine
pH 7.6, 30°C
Rhodococcus opacus
L-tyrosine
; pH 7.6, 30°C
Rhodococcus opacus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
L-Lys
pH 7.6, 30°C
Rhodococcus opacus
0.015
-
L-lysine
pH 7.6, 30°C
Rhodococcus opacus
0.019
-
L-Tyr
pH 7.6, 30°C
Rhodococcus opacus
0.019
-
L-tyrosine
pH 7.6, 30°C
Rhodococcus opacus
0.022
-
L-Phe
pH 7.6, 30°C
Rhodococcus opacus
0.022
-
L-phenylalanine
pH 7.6, 30°C
Rhodococcus opacus
0.026
-
L-citrulline
pH 7.6, 30°C
Rhodococcus opacus
0.026
-
L-norleucine
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-Asp
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-asparagine
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-Leu
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-leucine
pH 7.6, 30°C
Rhodococcus opacus
0.034
-
L-Orn
pH 7.6, 30°C
Rhodococcus opacus
0.034
-
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
0.039
-
L-Met
pH 7.6, 30°C
Rhodococcus opacus
0.039
-
L-methionine
pH 7.6, 30°C
Rhodococcus opacus
0.07
-
L-Arg
pH 7.6, 30°C
Rhodococcus opacus
0.07
-
L-arginine
pH 7.6, 30°C
Rhodococcus opacus
0.085
-
L-Gln
pH 7.6, 30°C
Rhodococcus opacus
0.085
-
L-glutamine
pH 7.6, 30°C
Rhodococcus opacus
0.274
-
L-Ala
pH 7.6, 30°C
Rhodococcus opacus
0.274
-
L-alanine
pH 7.6, 30°C
Rhodococcus opacus
0.411
-
L-Glu
pH 7.6, 30°C
Rhodococcus opacus
0.411
-
L-Glutamic acid
pH 7.6, 30°C
Rhodococcus opacus
1.36
-
L-Ser
pH 7.6, 30°C
Rhodococcus opacus
1.36
-
L-serine
pH 7.6, 30°C
Rhodococcus opacus
3.73
-
L-Val
pH 7.6, 30°C
Rhodococcus opacus
3.73
-
L-valine
pH 7.6, 30°C
Rhodococcus opacus
5.11
-
L-Ile
pH 7.6, 30°C
Rhodococcus opacus
5.11
-
L-isoleucine
pH 7.6, 30°C
Rhodococcus opacus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53000
-
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
53200
-
x * 53200, SDS-PAGE
Rhodococcus opacus
54000
-
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
99000
-
gel filtartion; gel filtration
Rhodococcus opacus
104000
-
MALDI-TOF/MS
Rhodococcus opacus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rhodococcus opacus
Q8VPD4
DSM 43250; DSM 43250, one of the best L-AAO producer
-
Purification (Commentary)
Commentary
Organism
to homogeneity, recovery of 68% and 144fold
Rhodococcus opacus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
4.6
-
homogenous enzyme, L-alanine as susbtrate, 30°C, pH 7.6
Rhodococcus opacus
4.61
-
-
Rhodococcus opacus
Storage Stability
Storage Stability
Organism
-18°C, 50 mM glycine/NaOH buffer, pH 8.6, 50% glycerol, stable for several months, withou glycerol inactivation
Rhodococcus opacus
4°C or -18°C, pH 8.6, 50 mM glycine/NaOH buffer, 50% glycerol, stable for several months
Rhodococcus opacus
4°C, 50 mM glycine/NaOH buffer, pH 8.6, stable for several months
Rhodococcus opacus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-3-(1-pyridyl)-alanine + H2O + O2
24% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-3-(1-pyridyl)alanine + H2O + O2
24% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1-pyridyl)pyruvate + NH3 + H2O2
-
-
-
?
DL-4-fluorophenylalanine + H2O + O2
25% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-4-fluorophenylalanine + H2O + O2
25% of the activity with L-Ala
651026
Rhodococcus opacus
(4-fluorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
DL-beta-phenylserine + H2O + O2
8% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
DL-homophenylalanine + H2O + O2
50% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-4-phenylbutanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-homophenylalanine + H2O + O2
50% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-4-phenylbutyric acid + NH3 + H2O2
-
-
-
?
DL-norleucine + H2O + O2
73% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-ketocaproate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-norleucine + H2O + O2
73% of the activity with L-Ala
651026
Rhodococcus opacus
alpha-ketocaproate + NH3 + H2O2
-
-
-
?
DL-O-methylserine + H2O + O2
99% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-O-methylserine + H2O + O2
99% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
DL-phenylseine + H2O + O2
8% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,3-diaminopropionic acid + H2O + O2
71% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,3-diaminopropionic acid + H2O + O2
71% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-2,4-diaminobutyric acid + H2O + O2
100% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-amino-2-oxobutanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,4-diaminobutyric acid + H2O + O2
as active as L-Ala
651026
Rhodococcus opacus
4-amino-2-oxobutanoate + NH3 + H2O2
-
-
-
?
L-2-4,4,dimethylvaleric acid + H2O + O2
46% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-amino-4,4-dimethylhexanoic acid + H2O + O2
44% of the activity with L-Ala
651026
Rhodococcus opacus
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-2-amino-4,4-dimethylvaleric acid + H2O + O2
46% of the activity with L-Ala
651026
Rhodococcus opacus
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-2-amino-5,5-dimethylhexanoic acid + H2O + O2
44% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-chlorophenylalanine + H2O + O2
24% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-chlorophenylalanine + H2O + O2
24% of the activity with L-Ala
651026
Rhodococcus opacus
(2-chlorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-3-(1-naphthyl)alanine + H2O + O2
109% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1-naphthyl)pyruvate + NH3 + H2O2
-
-
-
?
L-3-(naphthyl)alanine + H2O + O2
109% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-aminophenylalanine + H2O + O2
16% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-aminophenylalanine + H2O + O2
16% of the activity with L-Ala
651026
Rhodococcus opacus
(4-aminophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-4-chlorophenylalanine + H2O + O2
9% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-chlorophenylalanine + H2O + O2
9% of the activity with L-Ala
651026
Rhodococcus opacus
(4-chlorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-4-nitrophenylalanine + H2O + O2
30% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-nitrophenylalanine + H2O + O2
30% of the activity with L-Ala
651026
Rhodococcus opacus
(4-nitrophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-Ala + H2O + O2
-
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
L-alanine + H2O + O2
highly enantioselective enzyme with a broad substrate specificity
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Arg + H2O + O2
70% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
70% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Asp + H2O + O2
11% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-Asp + H2O + O2
97% of the activity with L-Ala
651026
Rhodococcus opacus
alpha-ketosuccinamic acid + NH3 + H2O2
-
-
-
?
L-asparagine + H2O + O2
97% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-ketosuccinamic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-aspartic acid + H2O + O2
11% of the activity compared to L-alanine
651026
Rhodococcus opacus
oxaloacetate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-citrulline + H2O + O2
74% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-citrulline + H2O + O2
74% of the activity with L-Ala
651026
Rhodococcus opacus
N5-carbamoyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-cysteic acid + H2O + O2
34% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-cysteic acid + H2O + O2
34% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-cystine + H2O + O2
104% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-cystine + H2O + O2
104% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Gln + H2O + O2
52% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-Glu + H2O + O2
52% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-glutamic acid + H2O + O2
52% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-glutamine + H2O + O2
52% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-His + H2O + O2
36% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
36% of the activity compared to L-alanine
651026
Rhodococcus opacus
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homocysteine thiolactone + H2O + O2
23% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homocysteine thiolactone + H2O + O2
23% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-homoserine lactone + H2O + O2
66% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homoserine lactone + H2O + O2
66% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-Ile + H2O + O2
45% of the activity with L-Ala
651026
Rhodococcus opacus
3-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-isoleucine + H2O + O2
45% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Leu + H2O + O2
68% of the activity with L-Ala
651026
Rhodococcus opacus
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
68% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Lys + H2O + O2
55% of the activity with L-Ala
651026
Rhodococcus opacus
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
-
-
?
L-lysine + H2O + O2
55% of the activity compared to L-alanine
651026
Rhodococcus opacus
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Met + H2O + O2
72% of the activity with L-Ala
651026
Rhodococcus opacus
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
L-methionine + H2O + O2
72% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Orn + H2O + O2
117% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-5-aminopentanoate + NH3 + H2O2
-
-
-
?
L-ornithine + H2O + O2
117% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-5-aminopentanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Phe + H2O + O2
53% of the activity with L-Ala
651026
Rhodococcus opacus
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + H2O + O2
53% of the activity compared to L-alanine
651026
Rhodococcus opacus
phenylpyruvate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-phenylglycine + H2O + O2
5% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-phenylglycine + H2O + O2
5% of the activity with L-Ala
651026
Rhodococcus opacus
phenylacetate + NH3 + H2O2
-
-
-
?
L-Ser + H2O + O2
72% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
?
L-serine + H2O + O2
72% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Trp + H2O + O2
12% of the activity with L-Ala
651026
Rhodococcus opacus
indole-3-pyruvate + NH3 + H2O2
-
-
-
?
L-tryptophan + H2O + O2
12% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Tyr + H2O + O2
54% of the activity with L-Ala
651026
Rhodococcus opacus
p-hydroxyphenylpyruvate + NH3 + H2O2
-
-
-
?
L-tyrosine + H2O + O2
54% of the activity compared to L-alanine
651026
Rhodococcus opacus
p-hydroxyphenylpyruvate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Val + H2O + O2
32% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoisovalerate + NH3 + H2O2
-
-
-
?
L-valine + H2O + O2
32% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxoisovalerate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
Nepsilon-acetyl-L-Lys + H2O + O2
46% of the activity with L-Ala
651026
Rhodococcus opacus
6-acetylamino-2-oxohexanoic acid + NH3 + H2O2
-
-
-
?
Nepsilon-acetyl-L-lysine + H2O + O2
46% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
Subunits
Subunits
Commentary
Organism
?
x * 53200, SDS-PAGE
Rhodococcus opacus
dimer
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
25
50
inactivation in 50 mM triethylamine/HCl buffer, pH 7.6 in the same range as 50 mM potassium-phosphate buffer pH 6.6
Rhodococcus opacus
30
-
incubation for 30 min with 0.28 M H2O2 results in 50% inactivation
Rhodococcus opacus
37
-
half-life: 938 min in glycine/NaOH buffer, 35 min in TEA/HCL buffer and 44 min in potassium phosphate buffer; t1/2: 35 min, increases more than 20fold by incubating the L-AAO in glycine/NaOH buffer: 938 min, potassium phosphate buffer t1/2: 44 min
Rhodococcus opacus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
9
; for 10 mM L-alanine, L-leucine, L-phenylalanine, the pH-profiles are almost identical
Rhodococcus opacus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
4
11
L-phenylalanine as substrate, pH 4: ca. 10% of the activity, pH 11: ca. 60% of the activity
Rhodococcus opacus
4.5
10.5
L-alanine as substrate, pH 4.5, ca. 3% of the activity, pH 10.5, ca. 30% of the activity
Rhodococcus opacus
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
a homodimer complex containing 2 FAD molecules
Rhodococcus opacus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.06
-
L-Tyr
pH 7.6, 30°C
Rhodococcus opacus
1.06
-
L-tyrosine
pH 7.6, 30°C
Rhodococcus opacus
2.28
-
L-Phe
pH 7.6, 30°C
Rhodococcus opacus
2.28
-
L-phenylalanine
pH 7.6, 30°C
Rhodococcus opacus
2.91
-
L-norleucine
pH 7.6, 30°C; pH 7.6, 30°C
Rhodococcus opacus
4.5
-
Gly
pH 7.6, 30°C
Rhodococcus opacus
4.5
-
glycine
pH 7.6, 30°C
Rhodococcus opacus
5.42
-
L-Arg
pH 7.6, 30°C
Rhodococcus opacus
5.42
-
L-arginine
pH 7.6, 30°C
Rhodococcus opacus
5.69
-
L-Leu
pH 7.6, 30°C
Rhodococcus opacus
5.69
-
L-leucine
pH 7.6, 30°C
Rhodococcus opacus
6.84
-
L-Met
pH 7.6, 30°C
Rhodococcus opacus
6.84
-
L-methionine
pH 7.6, 30°C
Rhodococcus opacus
12.5
-
L-Orn
pH 7.6, 30°C
Rhodococcus opacus
12.5
-
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
20.6
-
L-citrulline
pH 7.6, 30°C; pH 7.6, 30°C
Rhodococcus opacus
63.7
-
L-Lys
pH 7.6, 30°C
Rhodococcus opacus
63.7
-
L-lysine
pH 7.6, 30°C
Rhodococcus opacus
192
-
L-Ser
pH 7.6, 30°C
Rhodococcus opacus
192
-
L-serine
pH 7.6, 30°C
Rhodococcus opacus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Rhodococcus opacus
isoelectric focusing, using a narrow pH-range of 4-6
-
4.8
Rhodococcus opacus
-
-
4.9
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
a homodimer complex containing 2 FAD molecules
Rhodococcus opacus
General Stability (protein specific)
General Stability
Organism
freezing at -18°C without addition of glycerol inactivates the enzyme
Rhodococcus opacus
stability of the enzyme can be increased by storage or incubation of the enzyme in glycine/NaOH buffer
Rhodococcus opacus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Gly
competitive inhibition of reaction with L-Ala, does not reduce activity when 10 mM L-Phe is used as substrate
Rhodococcus opacus
glycine
activity strongly decreased in glycine/NaOH-buffer, competitive inhibition, no inhibition, when 10 mM L-phenylanalnine is used as substrate
Rhodococcus opacus
L-arginine
pH 7.6, 30°C
Rhodococcus opacus
L-arginine
-
Rhodococcus opacus
L-citrulline
pH 7.6, 30°C
Rhodococcus opacus
L-citrulline
-
Rhodococcus opacus
L-leucine
pH 7.6, 30°C
Rhodococcus opacus
L-leucine
-
Rhodococcus opacus
L-lysine
pH 7.6, 30°C
Rhodococcus opacus
L-lysine
-
Rhodococcus opacus
L-methionine
pH 7.6, 30°C
Rhodococcus opacus
L-methionine
-
Rhodococcus opacus
L-norleucine
pH 7.6, 30°C
Rhodococcus opacus
L-norleucine
-
Rhodococcus opacus
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
L-phenylalanine
pH 7.6, 30°C
Rhodococcus opacus
L-phenylalanine
-
Rhodococcus opacus
L-serine
pH 7.6, 30°C
Rhodococcus opacus
L-tyrosine
pH 7.6, 30°C
Rhodococcus opacus
L-tyrosine
-
Rhodococcus opacus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.06
-
L-Tyr
pH 7.6, 30°C
Rhodococcus opacus
1.06
-
L-tyrosine
pH 7.6, 30°C
Rhodococcus opacus
2.28
-
L-Phe
pH 7.6, 30°C
Rhodococcus opacus
2.28
-
L-phenylalanine
pH 7.6, 30°C
Rhodococcus opacus
2.91
-
L-norleucine
pH 7.6, 30°C
Rhodococcus opacus
4.5
-
Gly
pH 7.6, 30°C
Rhodococcus opacus
4.5
-
glycine
pH 7.6, 30°C
Rhodococcus opacus
5.42
-
L-Arg
pH 7.6, 30°C
Rhodococcus opacus
5.42
-
L-arginine
pH 7.6, 30°C
Rhodococcus opacus
5.69
-
L-Leu
pH 7.6, 30°C
Rhodococcus opacus
5.69
-
L-leucine
pH 7.6, 30°C
Rhodococcus opacus
6.84
-
L-Met
pH 7.6, 30°C
Rhodococcus opacus
6.84
-
L-methionine
pH 7.6, 30°C
Rhodococcus opacus
12.5
-
L-Orn
pH 7.6, 30°C
Rhodococcus opacus
12.5
-
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
20.6
-
L-citrulline
pH 7.6, 30°C
Rhodococcus opacus
63.7
-
L-Lys
pH 7.6, 30°C
Rhodococcus opacus
63.7
-
L-lysine
pH 7.6, 30°C
Rhodococcus opacus
192
-
L-Ser
pH 7.6, 30°C
Rhodococcus opacus
192
-
L-serine
pH 7.6, 30°C
Rhodococcus opacus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
L-Lys
pH 7.6, 30°C
Rhodococcus opacus
0.015
-
L-lysine
pH 7.6, 30°C
Rhodococcus opacus
0.019
-
L-Tyr
pH 7.6, 30°C
Rhodococcus opacus
0.019
-
L-tyrosine
pH 7.6, 30°C
Rhodococcus opacus
0.022
-
L-Phe
pH 7.6, 30°C
Rhodococcus opacus
0.022
-
L-phenylalanine
pH 7.6, 30°C
Rhodococcus opacus
0.026
-
L-citrulline
pH 7.6, 30°C
Rhodococcus opacus
0.026
-
L-norleucine
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-Asp
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-asparagine
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-Leu
pH 7.6, 30°C
Rhodococcus opacus
0.028
-
L-leucine
pH 7.6, 30°C
Rhodococcus opacus
0.034
-
L-Orn
pH 7.6, 30°C
Rhodococcus opacus
0.034
-
L-ornithine
pH 7.6, 30°C
Rhodococcus opacus
0.039
-
L-Met
pH 7.6, 30°C
Rhodococcus opacus
0.039
-
L-methionine
pH 7.6, 30°C
Rhodococcus opacus
0.07
-
L-Arg
pH 7.6, 30°C
Rhodococcus opacus
0.07
-
L-arginine
pH 7.6, 30°C
Rhodococcus opacus
0.085
-
L-Gln
pH 7.6, 30°C
Rhodococcus opacus
0.085
-
L-glutamine
pH 7.6, 30°C
Rhodococcus opacus
0.274
-
L-Ala
pH 7.6, 30°C
Rhodococcus opacus
0.274
-
L-alanine
pH 7.6, 30°C
Rhodococcus opacus
0.411
-
L-Glu
pH 7.6, 30°C
Rhodococcus opacus
0.411
-
L-Glutamic acid
pH 7.6, 30°C
Rhodococcus opacus
1.36
-
L-Ser
pH 7.6, 30°C
Rhodococcus opacus
1.36
-
L-serine
pH 7.6, 30°C
Rhodococcus opacus
3.73
-
L-Val
pH 7.6, 30°C
Rhodococcus opacus
3.73
-
L-valine
pH 7.6, 30°C
Rhodococcus opacus
5.11
-
L-Ile
pH 7.6, 30°C
Rhodococcus opacus
5.11
-
L-isoleucine
pH 7.6, 30°C
Rhodococcus opacus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53000
-
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
53200
-
x * 53200, SDS-PAGE
Rhodococcus opacus
54000
-
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
99000
-
gel filtartion; gel filtration
Rhodococcus opacus
104000
-
MALDI-TOF/MS
Rhodococcus opacus
Purification (Commentary) (protein specific)
Commentary
Organism
to homogeneity, recovery of 68% and 144fold
Rhodococcus opacus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
4.6
-
homogenous enzyme, L-alanine as susbtrate, 30°C, pH 7.6
Rhodococcus opacus
4.61
-
-
Rhodococcus opacus
Storage Stability (protein specific)
Storage Stability
Organism
-18°C, 50 mM glycine/NaOH buffer, pH 8.6, 50% glycerol, stable for several months, withou glycerol inactivation
Rhodococcus opacus
4°C or -18°C, pH 8.6, 50 mM glycine/NaOH buffer, 50% glycerol, stable for several months
Rhodococcus opacus
4°C, 50 mM glycine/NaOH buffer, pH 8.6, stable for several months
Rhodococcus opacus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-3-(1-pyridyl)-alanine + H2O + O2
24% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-3-(1-pyridyl)alanine + H2O + O2
24% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1-pyridyl)pyruvate + NH3 + H2O2
-
-
-
?
DL-4-fluorophenylalanine + H2O + O2
25% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-4-fluorophenylalanine + H2O + O2
25% of the activity with L-Ala
651026
Rhodococcus opacus
(4-fluorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
DL-beta-phenylserine + H2O + O2
8% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
DL-homophenylalanine + H2O + O2
50% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-4-phenylbutanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-homophenylalanine + H2O + O2
50% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-4-phenylbutyric acid + NH3 + H2O2
-
-
-
?
DL-norleucine + H2O + O2
73% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-ketocaproate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-norleucine + H2O + O2
73% of the activity with L-Ala
651026
Rhodococcus opacus
alpha-ketocaproate + NH3 + H2O2
-
-
-
?
DL-O-methylserine + H2O + O2
99% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
DL-O-methylserine + H2O + O2
99% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
DL-phenylseine + H2O + O2
8% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,3-diaminopropionic acid + H2O + O2
71% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,3-diaminopropionic acid + H2O + O2
71% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-2,4-diaminobutyric acid + H2O + O2
100% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-amino-2-oxobutanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2,4-diaminobutyric acid + H2O + O2
as active as L-Ala
651026
Rhodococcus opacus
4-amino-2-oxobutanoate + NH3 + H2O2
-
-
-
?
L-2-4,4,dimethylvaleric acid + H2O + O2
46% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-amino-4,4-dimethylhexanoic acid + H2O + O2
44% of the activity with L-Ala
651026
Rhodococcus opacus
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-2-amino-4,4-dimethylvaleric acid + H2O + O2
46% of the activity with L-Ala
651026
Rhodococcus opacus
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-2-amino-5,5-dimethylhexanoic acid + H2O + O2
44% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-chlorophenylalanine + H2O + O2
24% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-2-chlorophenylalanine + H2O + O2
24% of the activity with L-Ala
651026
Rhodococcus opacus
(2-chlorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-3-(1-naphthyl)alanine + H2O + O2
109% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1-naphthyl)pyruvate + NH3 + H2O2
-
-
-
?
L-3-(naphthyl)alanine + H2O + O2
109% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-aminophenylalanine + H2O + O2
16% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-aminophenylalanine + H2O + O2
16% of the activity with L-Ala
651026
Rhodococcus opacus
(4-aminophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-4-chlorophenylalanine + H2O + O2
9% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-chlorophenylalanine + H2O + O2
9% of the activity with L-Ala
651026
Rhodococcus opacus
(4-chlorophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-4-nitrophenylalanine + H2O + O2
30% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-4-nitrophenylalanine + H2O + O2
30% of the activity with L-Ala
651026
Rhodococcus opacus
(4-nitrophenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-Ala + H2O + O2
-
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
L-alanine + H2O + O2
highly enantioselective enzyme with a broad substrate specificity
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Arg + H2O + O2
70% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
70% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Asp + H2O + O2
11% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-Asp + H2O + O2
97% of the activity with L-Ala
651026
Rhodococcus opacus
alpha-ketosuccinamic acid + NH3 + H2O2
-
-
-
?
L-asparagine + H2O + O2
97% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-ketosuccinamic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-aspartic acid + H2O + O2
11% of the activity compared to L-alanine
651026
Rhodococcus opacus
oxaloacetate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-citrulline + H2O + O2
74% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-citrulline + H2O + O2
74% of the activity with L-Ala
651026
Rhodococcus opacus
N5-carbamoyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-cysteic acid + H2O + O2
34% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-cysteic acid + H2O + O2
34% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-cystine + H2O + O2
104% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-cystine + H2O + O2
104% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Gln + H2O + O2
52% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-Glu + H2O + O2
52% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-glutamic acid + H2O + O2
52% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxoglutarate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-glutamine + H2O + O2
52% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxopropanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-His + H2O + O2
36% of the activity with L-Ala
651026
Rhodococcus opacus
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
36% of the activity compared to L-alanine
651026
Rhodococcus opacus
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homocysteine thiolactone + H2O + O2
23% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homocysteine thiolactone + H2O + O2
23% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-homoserine lactone + H2O + O2
66% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-homoserine lactone + H2O + O2
66% of the activity with L-Ala
651026
Rhodococcus opacus
? + NH3 + H2O2
-
-
-
?
L-Ile + H2O + O2
45% of the activity with L-Ala
651026
Rhodococcus opacus
3-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-isoleucine + H2O + O2
45% of the activity compared to L-alanine
651026
Rhodococcus opacus
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Leu + H2O + O2
68% of the activity with L-Ala
651026
Rhodococcus opacus
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
68% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Lys + H2O + O2
55% of the activity with L-Ala
651026
Rhodococcus opacus
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
-
-
?
L-lysine + H2O + O2
55% of the activity compared to L-alanine
651026
Rhodococcus opacus
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Met + H2O + O2
72% of the activity with L-Ala
651026
Rhodococcus opacus
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
L-methionine + H2O + O2
72% of the activity compared to L-alanine
651026
Rhodococcus opacus
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Orn + H2O + O2
117% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-5-aminopentanoate + NH3 + H2O2
-
-
-
?
L-ornithine + H2O + O2
117% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-5-aminopentanoate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Phe + H2O + O2
53% of the activity with L-Ala
651026
Rhodococcus opacus
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + H2O + O2
53% of the activity compared to L-alanine
651026
Rhodococcus opacus
phenylpyruvate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-phenylglycine + H2O + O2
5% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-phenylglycine + H2O + O2
5% of the activity with L-Ala
651026
Rhodococcus opacus
phenylacetate + NH3 + H2O2
-
-
-
?
L-Ser + H2O + O2
72% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
?
L-serine + H2O + O2
72% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Trp + H2O + O2
12% of the activity with L-Ala
651026
Rhodococcus opacus
indole-3-pyruvate + NH3 + H2O2
-
-
-
?
L-tryptophan + H2O + O2
12% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Tyr + H2O + O2
54% of the activity with L-Ala
651026
Rhodococcus opacus
p-hydroxyphenylpyruvate + NH3 + H2O2
-
-
-
?
L-tyrosine + H2O + O2
54% of the activity compared to L-alanine
651026
Rhodococcus opacus
p-hydroxyphenylpyruvate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
L-Val + H2O + O2
32% of the activity with L-Ala
651026
Rhodococcus opacus
2-oxoisovalerate + NH3 + H2O2
-
-
-
?
L-valine + H2O + O2
32% of the activity compared to L-alanine
651026
Rhodococcus opacus
2-oxoisovalerate + NH3 + H2O2
-
651026
Rhodococcus opacus
?
Nepsilon-acetyl-L-Lys + H2O + O2
46% of the activity with L-Ala
651026
Rhodococcus opacus
6-acetylamino-2-oxohexanoic acid + NH3 + H2O2
-
-
-
?
Nepsilon-acetyl-L-lysine + H2O + O2
46% of the activity compared to L-alanine
651026
Rhodococcus opacus
? + NH3 + H2O2
-
651026
Rhodococcus opacus
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 53200, SDS-PAGE
Rhodococcus opacus
dimer
2 * 53000, SDS-PAGE, 2 * 54000, MALDI-TOF/MS, correlates with a homodimer containing 2 FAD molecules
Rhodococcus opacus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
25
50
inactivation in 50 mM triethylamine/HCl buffer, pH 7.6 in the same range as 50 mM potassium-phosphate buffer pH 6.6
Rhodococcus opacus
30
-
incubation for 30 min with 0.28 M H2O2 results in 50% inactivation
Rhodococcus opacus
37
-
half-life: 938 min in glycine/NaOH buffer, 35 min in TEA/HCL buffer and 44 min in potassium phosphate buffer; t1/2: 35 min, increases more than 20fold by incubating the L-AAO in glycine/NaOH buffer: 938 min, potassium phosphate buffer t1/2: 44 min
Rhodococcus opacus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
9
; for 10 mM L-alanine, L-leucine, L-phenylalanine, the pH-profiles are almost identical
Rhodococcus opacus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
4
11
L-phenylalanine as substrate, pH 4: ca. 10% of the activity, pH 11: ca. 60% of the activity
Rhodococcus opacus
4.5
10.5
L-alanine as substrate, pH 4.5, ca. 3% of the activity, pH 10.5, ca. 30% of the activity
Rhodococcus opacus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Rhodococcus opacus
isoelectric focusing, using a narrow pH-range of 4-6
-
4.8
Rhodococcus opacus
-
-
4.9
Other publictions for EC 1.4.3.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741725
Hahn
Recombinant expression and ch ...
Rhizoctonia solani
Appl. Microbiol. Biotechnol.
101
2853-2864
2017
1
-
1
-
-
-
-
7
-
-
-
-
-
3
-
-
1
-
-
-
-
-
17
1
-
-
-
7
-
1
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
7
-
-
-
-
-
-
-
1
-
-
-
-
17
1
-
-
-
7
-
1
-
-
-
-
-
-
7
7
742670
Carone
A new L-amino acid oxidase fr ...
Bothrops jararacussu
Int. J. Biol. Macromol.
103
25-35
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
743871
Feliciano
Crystal structure and molecul ...
Bothrops atrox
Toxicon
128
50-59
2017
-
-
-
1
-
-
-
-
-
1
-
1
-
2
-
1
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
1
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739920
Hou
Combination of phenylpyruvic a ...
Proteus mirabilis, Proteus mirabilis KCTC 2566
Appl. Microbiol. Biotechnol.
100
2183-2191
2016
-
1
1
-
8
-
-
9
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
9
-
-
-
-
-
-
-
-
1
1
-
-
8
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
9
-
-
-
-
-
-
-
-
9
9
740922
Ju
Crystal structure of a membran ...
Proteus vulgaris
J. Struct. Biol.
195
306-315
2016
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742687
Abdelkafi-Koubaa
Interaction of a snake venom ...
Cerastes cerastes
Int. J. Biol. Macromol.
82
757-764
2016
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742690
Ribeiro
Mechanism of the cytotoxic ef ...
Bothrops alternatus
Int. J. Biol. Macromol.
92
329-337
2016
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
743869
Teixeira
Isolation, characterization a ...
Crotalus durissus terrificus
Toxicon
119
203-217
2016
-
-
-
-
-
-
-
4
-
-
1
8
-
5
-
-
1
-
-
1
-
-
8
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
8
-
-
-
1
-
1
-
-
8
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
743870
Burin
The L-amino acid oxidase from ...
Calloselasma rhodostoma
Toxicon
120
9-14
2016
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741749
Kasai
Recombinant production and ev ...
Platichthys stellatus
Appl. Microbiol. Biotechnol.
99
6693-6703
2015
-
-
1
-
-
-
-
-
-
-
-
13
-
1
-
-
1
-
-
-
-
-
13
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
13
-
-
-
1
-
-
-
-
13
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742041
Aitken
Characterization of an L-amin ...
Equus caballus
Biol. Reprod.
92
125
2015
-
-
-
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742345
Kitani
Identification of the Atlanti ...
Gadus morhua
Dev. Comp. Immunol.
50
116-120
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
743013
El Hakim
-
Heterodimeric lL-amino acid o ...
Cerastes cerastes
J. Gen. Eng. Biotechnol.
13
165-176
2015
-
-
-
-
-
-
13
2
-
2
1
-
-
1
-
-
1
-
-
1
-
-
8
1
2
-
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
13
-
2
-
2
1
-
-
-
-
1
-
1
-
-
8
1
2
-
1
-
2
-
1
-
-
-
-
-
-
-
743868
Dantas
L-amino acid oxidase from Bot ...
Bothrops marajoensis
Toxicon
104
52-56
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
741595
Sun
Development of new chiral lig ...
Crotalus atrox
Anal. Chim. Acta
821
97-102
2014
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741737
Hossain
L-Amino acid oxidases from mi ...
Aspergillus nidulans, Bacillus subtilis, Corynebacterium sp., Corynebacterium sp. A20, Escherichia coli, Marinomonas mediterranea, Neisseria meningitidis, Proteus mirabilis, Proteus vulgaris, Providencia alcalifaciens, Pseudomonas putida, Pseudomonas sp., Pseudomonas sp. P501, Rhodococcus opacus, Streptomyces sp., Trichoderma harzianum, Trichoderma harzianum ETS 323, Trichoderma viride
Appl. Microbiol. Biotechnol.
98
1507-1515
2014
-
-
-
-
-
-
-
-
-
-
-
210
-
21
-
-
-
-
-
-
-
-
210
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
210
-
-
-
-
-
-
-
-
210
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742047
Izidoro
Snake venom L-amino acid oxid ...
Aplysia punctata, Bothrops alternatus, Bothrops atrox, Bothrops insularis, Bothrops jararaca, Bothrops leucurus, Bothrops marajoensis, Bothrops pauloensis, Bothrops pirajai, Bungarus caeruleus, Bungarus fasciatus, Calloselasma rhodostoma, Crotalus durissus cumanensis, Daboia russelii, Deinagkistrodon acutus, Gloydius ussuriensis, Lachesis muta, Macrovipera lebetina, Naja oxiana, Ophiophagus hannah, Vipera berus berus
BioMed Res. Int.
2014
196754
2014
-
-
-
-
-
-
-
28
-
-
-
80
-
21
-
-
20
-
-
21
-
-
80
20
-
-
-
27
-
-
-
21
-
11
-
-
-
-
21
-
-
-
-
-
-
28
-
-
-
80
-
-
-
20
-
21
-
-
80
20
-
-
-
27
-
-
-
11
-
20
20
-
-
-
742530
Matsui
Mutational and crystallograph ...
Pseudomonas sp. AIU 813
FEBS Open Bio
4
220-228
2014
1
-
1
1
1
-
-
-
-
-
-
3
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
1
1
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742813
Hanane-Fadila
Purification, characterizatio ...
Cerastes cerastes
J. Biochem. Mol. Toxicol.
28
347-354
2014
-
-
-
-
-
1
-
1
-
-
-
-
-
9
-
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
742930
Isobe
Characterization of a novel L ...
Penicillium steckii, Penicillium steckii AIU 027
J. Biosci. Bioeng.
117
690-695
2014
-
-
-
-
-
-
17
12
-
2
1
-
-
3
-
-
1
-
-
1
-
-
23
1
-
-
1
-
-
-
1
1
-
1
-
-
-
-
1
-
-
-
-
17
-
12
-
2
1
-
-
-
-
1
-
1
-
-
23
1
-
-
1
-
-
-
1
1
-
-
-
-
-
-
743071
Singh
-
Aspergillus fumigatus L-amino ...
Aspergillus fumigatus
J. Microb. Biochem. Technol.
6
96-101
2014
-
-
-
-
-
-
12
1
-
2
1
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1
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1
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8
1
1
1
1
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1
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12
-
1
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2
1
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1
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8
1
1
1
1
-
1
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-
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-
-
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-
-
743849
Yu
Identification, cloning, and ...
Pseudoalteromonas sp., Pseudoalteromonas sp. B3
ScientificWorldJournal
2014
979858
2014
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1
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5
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1
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1
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2
1
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743872
Abdelkafi-Koubaa
A thermoactive L-amino acid o ...
Cerastes cerastes
Toxicon
89
32-44
2014
-
-
-
-
-
-
1
3
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1
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1
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1
1
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1
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1
1
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1
3
1
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1
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1
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1
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1
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3
-
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1
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1
1
-
1
-
1
4
1
1
-
1
3
1
-
-
1
-
-
-
-
3
3
724814
Kitani
Intra-tissue localization of a ...
Sebastes schlegelii
Dev. Comp. Immunol.
39
456-459
2013
-
-
-
-
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1
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5
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1
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1
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1
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5
-
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1
-
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-
-
1
1
-
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-
725027
Mitra
Irreversible inactivation of s ...
Crotalus adamanteus, Crotalus atrox
FEBS open bio
3
135-143
2013
-
-
-
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2
4
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2
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2
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6
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4
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2
2
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2
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2
2
4
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2
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6
-
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4
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726320
Puiffe
Antibacterial properties of th ...
Homo sapiens
PLoS ONE
8
e54589
2013
-
-
-
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-
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-
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-
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2
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2
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2
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2
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1
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1
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2
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
726521
Vargas
Cloning and characterization o ...
Crotalus durissus cumanensis
Toxicon
64
1-11
2013
-
-
-
-
-
-
-
1
-
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2
1
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1
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1
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1
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1
1
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1
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1
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1
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1
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1
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2
1
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1
-
1
-
-
1
1
-
-
-
1
-
-
-
1
-
1
1
-
1
1
741736
Pollegioni
L-amino acid oxidase as bioca ...
Aspergillus fumigatus, Bacillus carotarum, Hebeloma cylindrosporum, Pseudoalteromonas flavipulchra, Pseudoalteromonas luteoviolacea, Rhodococcus opacus, Rhodococcus opacus DSM 43250, Rhodococcus sp., Rhodococcus sp. AIU LAB-3, Rhodococcus sp. AIU Z-35-1, Trichoderma harzianum, Trichoderma harzianum ETS 323
Appl. Microbiol. Biotechnol.
97
9323-9341
2013
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-
-
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5
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6
63
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1
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63
6
2
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1
3
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9
-
3
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-
-
9
-
-
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-
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5
-
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6
63
-
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1
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-
63
6
2
-
-
1
3
-
-
3
-
-
-
-
-
-
743253
El-Sayed
-
Purification and characteriza ...
Aspergillus oryzae, Aspergillus oryzae ASH
Microbiology
82
762-771
2013
-
-
-
-
-
-
3
4
-
-
1
18
-
2
-
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1
-
-
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18
1
1
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1
4
1
1
1
1
-
1
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1
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3
-
4
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1
18
-
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1
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-
-
-
18
1
1
-
1
4
1
1
1
1
-
-
-
-
-
-
724190
Ullah
Structural insights into selec ...
Bothrops jararacussu
Biochem. Biophys. Res. Commun.
421
124-128
2012
-
-
-
1
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-
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1
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1
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6
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1
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1
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16
1
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1
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1
1
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1
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1
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1
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1
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-
16
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724397
Lukasheva
L-Amino acid oxidases: Propert ...
Achatina fulica, Aplysia californica, Bothrops alternatus, Bothrops jararaca, Bothrops moojeni, Bothrops pirajai, Crotalus durissus cascavella, Macrovipera lebetina, Mus musculus, Platichthys stellatus, Protobothrops jerdonii, Sebastes schlegelii, Trichoderma harzianum, Trimeresurus stejnegeri
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28
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18
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15
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28
-
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14
-
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14
-
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28
-
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15
-
-
28
-
-
-
-
-
-
-
-
-
-
14
14
-
-
-
724486
Chen
Cloning, characterization and ...
Daboia russelii
Biochimie
94
335-344
2012
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1
-
-
-
-
10
-
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3
1
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7
-
1
1
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3
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11
1
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1
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1
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1
1
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-
-
-
-
-
10
-
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3
1
-
-
1
1
-
3
-
-
11
1
-
-
-
-
-
-
-
1
-
-
-
-
10
10
725575
Isobe
Purification and characterizat ...
Pseudomonas sp.
J. Biosci. Bioeng.
114
257-261
2012
5
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-
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2
1
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1
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1
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2
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5
1
3
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2
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1
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1
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5
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1
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-
16
-
-
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2
1
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1
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2
-
5
1
3
-
-
-
2
-
-
1
1
-
-
1
-
-
726520
Bregge-Silva
Isolation and biochemical, fun ...
Lachesis muta
Toxicon
60
1263-1276
2012
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1
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-
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1
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4
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6
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1
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2
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10
1
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1
1
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1
-
1
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1
1
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-
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1
-
-
4
-
-
-
-
1
-
2
-
-
10
1
-
-
-
-
1
1
-
1
-
1
1
-
-
-
712998
Georgieva
The structure of a native L-am ...
Vipera ammodytes ammodytes
Mol. Biosyst.
7
379-384
2011
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-
-
1
-
-
-
-
1
1
-
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2
-
1
1
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-
1
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1
1
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1
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1
1
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1
1
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1
1
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1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
724964
Yang
Identification of antibacteria ...
Trichoderma harzianum, Trichoderma harzianum ETS 323
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278
3381-3394
2011
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1
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4
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6
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1
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-
-
-
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2
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1
1
1
4
1
1
1
1
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1
-
1
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-
4
-
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-
-
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1
-
-
-
-
2
-
1
1
1
4
1
1
1
-
-
1
1
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-
740632
Baek
Expression and characterizatio ...
Proteus mirabilis, Proteus mirabilis KCTC 2566
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51
129-135
2011
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1
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1
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8
1
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1
-
-
-
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1
1
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1
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-
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-
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-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
711329
Sun
Biochemical, functional and st ...
Gloydius ussuriensis
Biochimie
92
343-349
2010
-
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-
-
-
-
1
1
1
8
2
1
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10
-
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1
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3
1
-
1
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
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1
-
1
1
8
2
1
-
-
-
1
-
3
1
-
1
1
1
-
-
-
2
-
-
-
-
1
1
-
-
-
711786
Kitani
Discovery of serum L-amino aci ...
Sebastes schlegelii
Comp. Biochem. Physiol. B
157
351-356
2010
-
-
-
-
-
-
-
1
-
-
2
1
-
1
-
-
1
-
-
1
1
-
1
1
1
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1
1
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-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
2
1
-
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1
-
1
1
-
1
1
1
-
-
1
1
-
-
-
-
1
1
-
-
-
711791
Lee
Antibacterial action of a heat ...
Ophiophagus hannah
Comp. Biochem. Physiol. C
153
237-242
2010
-
-
-
-
-
-
-
-
-
-
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10
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3
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1
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1
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-
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3
-
-
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-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
711872
Chen
-
Involvement of an l-amino acid ...
Pseudoalteromonas flavipulchra, Pseudoalteromonas flavipulchra C2
Enzyme Microb. Technol.
47
52-58
2010
-
-
-
-
-
-
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-
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1
13
-
2
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-
-
-
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13
1
-
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3
-
-
-
-
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-
1
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-
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-
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-
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1
13
-
-
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-
-
-
-
-
13
1
-
-
3
-
-
-
-
1
-
1
1
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-
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711874
Isobe
A simple enzymatic method for ...
Rhodococcus sp., Rhodococcus sp. AIU Z-35-1
Enzyme Res.
2010
567210
2010
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1
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-
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2
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5
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-
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16
-
1
-
1
-
1
1
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
16
-
1
-
1
-
1
1
2
-
-
-
-
-
-
-
711980
Stasyk
A new highly toxic protein iso ...
Amanita phalloides
FEBS J.
277
1260-1269
2010
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1
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3
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-
-
-
2
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18
1
-
-
-
-
-
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-
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-
-
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-
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1
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-
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-
17
-
-
-
-
-
2
-
-
18
1
-
-
-
-
-
-
-
-
-
2
2
-
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-
711987
Kasai
Novel L-amino acid oxidase wit ...
Platichthys stellatus
FEBS J.
277
453-465
2010
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1
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1
-
1
1
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1
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1
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-
2
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1
1
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1
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-
1
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-
-
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1
-
1
1
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1
-
2
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-
1
1
-
-
-
-
-
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-
1
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713525
Qi
A chiral ligand exchange CE es ...
Crotalus atrox
Talanta
81
1554-1559
2010
-
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-
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1
1
1
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5
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1
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1
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5
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1
1
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1
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1
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-
1
-
-
-
-
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1
1
1
-
5
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-
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1
-
-
5
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1
1
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1
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713558
Costa Torres
Antibacterial and antiparasiti ...
Bothrops marajoensis
Toxicon
55
795-804
2010
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1
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1
2
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13
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1
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3
1
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1
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1
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1
-
1
2
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1
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1
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3
1
-
-
-
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-
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-
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713559
Deolindo
L-amino acid oxidase activity ...
Bothrops jararaca
Toxicon
56
944-955
2010
-
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1
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3
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1
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1
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1
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1
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1
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1
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696493
Rodrigues
Structural and functional prop ...
Bothrops pauloensis
Biochimie
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11
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13
2
1
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1
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1
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1
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1
1
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1
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2
1
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2
1
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1
11
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13
2
1
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1
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1
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697333
Kamio
The chemistry of escapin: iden ...
Aplysia californica, Aplysia californica Cooper 1863
Chemistry
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1
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1
1
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2
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1
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6
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1
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1
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697466
Nagashima
Isolation and cDNA cloning of ...
Myoxocephalus polyacanthocephalus
Comp. Biochem. Physiol. B
154
55-61
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2
2
1
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2
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1
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1
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1
1
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7
2
-
-
-
1
-
1
-
-
2
2
1
-
-
2
-
-
-
1
-
1
1
-
-
-
697859
Nagaoka
L-amino acid oxidase plays a c ...
Mus musculus
FASEB J.
23
2514-2520
2009
-
-
-
-
-
-
-
-
1
-
2
2
-
1
-
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-
-
2
-
-
2
1
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-
-
-
-
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-
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-
-
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1
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2
2
-
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-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698669
Fujisawa
Re-evaluation of M-LAO, L-amin ...
Gloydius blomhoffii
J. Biochem.
146
43-49
2009
-
-
-
-
-
-
2
-
-
-
1
1
-
3
-
1
1
-
-
1
-
-
3
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
1
-
-
1
1
-
1
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
699933
Carbonnelle-Puscian
The novel immunosuppressive en ...
Homo sapiens
Leukemia
23
952-960
2009
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
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-
-
1
-
-
-
1
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701330
Ciscotto
Antigenic, microbicidal and an ...
Bothrops jararaca
Toxicon
53
330-341
2009
-
-
-
-
-
-
-
-
1
-
1
1
-
23
-
2
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
2
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701332
Wei
Purification, characterization ...
Bungarus fasciatus
Toxicon
54
262-271
2009
-
-
-
-
-
-
-
14
1
-
2
1
-
6
-
-
1
-
-
1
-
-
16
1
1
-
-
14
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
1
-
2
1
-
-
-
1
-
1
-
-
16
1
1
-
-
14
1
-
-
-
-
-
-
-
-
-
701333
Zhong
Purification and characterizat ...
Daboia siamensis
Toxicon
54
763-771
2009
-
-
-
-
-
-
-
-
1
-
2
1
-
1
-
-
1
-
-
1
-
-
5
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
1
-
1
-
-
5
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
690221
Li
L-amino acid oxidase from Naja ...
Naja atra
Acta Biochim. Biophys. Sin.
40
19-26
2008
-
1
-
-
-
-
3
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
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-
-
-
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-
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-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690575
Gomez
The macromolecule with antimic ...
Pseudoalteromonas luteoviolacea, Pseudoalteromonas luteoviolacea CPMOR-1, Pseudoalteromonas luteoviolacea CPMOR-2, Pseudoalteromonas luteoviolacea NCIMB 1893T
Appl. Microbiol. Biotechnol.
79
925-930
2008
-
1
-
-
-
-
1
-
-
-
1
-
-
4
-
-
1
-
-
-
-
-
25
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
25
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690684
De Vieira Santos
Antitumoural effect of an L-am ...
Bothrops jararaca
Basic Clin. Pharmacol. Toxicol.
102
533-542
2008
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
5
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
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-
-
2
-
-
-
-
1
-
1
-
-
5
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
690856
Sant'Ana
Antiviral and antiparasite pro ...
Bothrops jararaca
Biochem. Pharmacol.
76
279-288
2008
-
1
-
-
-
-
1
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
691917
Kitani
Antibacterial action of L-amin ...
Sebastes schlegelii
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
149
394-400
2008
1
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691918
Samel
L-Amino acid oxidase from Naja ...
Naja oxiana
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
149
572-580
2008
-
1
-
-
-
-
1
4
-
-
2
-
-
5
-
-
1
-
-
1
11
1
6
2
-
-
1
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
4
-
-
2
-
-
-
-
1
-
1
11
1
6
2
-
-
1
4
-
-
-
1
-
-
-
-
-
-
692288
Mandal
Two L-amino acid oxidase isoen ...
Daboia russelii russelii
FEBS J.
275
2078-2095
2008
-
-
-
-
-
-
4
12
-
-
-
-
-
3
-
-
1
-
-
1
2
-
6
1
-
-
1
-
-
-
1
1
10
-
-
-
-
-
1
-
-
-
-
4
10
12
-
-
-
-
-
-
-
1
-
1
2
-
6
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
692863
Tong
SO-LAAO, a novel L-amino acid ...
Streptococcus cristatus
J. Bacteriol.
190
4716-4721
2008
1
1
1
-
1
-
-
-
-
-
1
-
-
7
-
-
1
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694300
Nuutinen
Identification of nitrogen min ...
Crotalus atrox, Hebeloma cylindrosporum, Hebeloma cylindrosporum CBS 558.96, Hebeloma sp., Laccaria bicolor, Laccaria bicolor S238N
Mycol. Res.
112
1453-1464
2008
1
3
-
-
-
-
-
2
-
-
-
-
-
7
-
-
-
-
-
2
-
1
25
-
-
-
-
-
3
1
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
1
25
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
694317
Zhang
Isolation and characterization ...
Deinagkistrodon acutus
Nat. Prod. Res.
22
554-563
2008
-
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
1
-
-
3
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695212
Braga
Purification and biological ef ...
Bothrops insularis
Toxicon
51
199-207
2008
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695276
Ande
Induction of apoptosis in yeas ...
Calloselasma rhodostoma
Yeast
25
349-357
2008
-
1
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695361
Georgieva
Isolation, crystallization and ...
Vipera ammodytes ammodytes
Acta Crystallogr. Sect. F
64
918-921
2008
-
-
-
1
-
-
-
-
1
-
1
1
-
3
-
-
1
-
-
3
-
-
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
1
1
-
-
-
1
-
3
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695637
Ko
Identification of potent bacte ...
Aplysia californica
Antimicrob. Agents Chemother.
52
4455-4462
2008
-
-
-
-
-
-
-
-
1
-
-
2
-
8
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
697450
Alves
Evidence of caspase-mediated a ...
Bothrops atrox
Comp. Biochem. Physiol. A
151
542-550
2008
-
-
-
-
-
-
-
-
1
-
1
-
-
4
-
1
1
-
-
1
1
-
7
2
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
1
-
1
1
-
7
2
-
-
-
-
1
-
-
1
-
1
1
-
-
-
668580
Kitani
Identification of an antibacte ...
Sebastes schlegelii
FEBS J.
274
125-136
2007
-
1
1
-
-
-
1
1
-
-
3
1
-
2
-
1
1
-
-
1
1
-
5
2
-
-
-
1
-
-
-
1
-
-
-
-
1
2
2
-
-
-
-
1
-
2
-
-
5
1
-
-
1
2
-
2
2
-
5
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
670798
Kommoju
Molecular cloning, expression ...
Calloselasma rhodostoma
Protein Expr. Purif.
52
89-95
2007
-
1
1
-
-
-
1
-
1
-
2
-
-
5
-
1
1
-
-
-
2
-
5
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
1
1
-
-
2
-
5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690693
Franca
Molecular approaches for struc ...
Bothrops jararacussu, Bothrops moojeni
Biochem. Biophys. Res. Commun.
355
302-306
2007
-
2
-
-
-
-
2
-
-
-
2
-
-
6
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
2
-
-
-
-
2
-
-
-
-
2
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
692408
Kitani
Gene expression and distributi ...
Sebastes schlegelii
Fish Shellfish Immunol.
23
1178-1186
2007
-
1
-
-
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
5
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
5
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692650
Stabeli
Cytotoxic L-amino acid oxidase ...
Bothrops moojeni
Int. J. Biol. Macromol.
41
132-140
2007
1
1
-
-
-
-
1
-
-
-
3
-
-
1
-
-
1
-
-
1
16
-
17
1
-
-
1
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
1
-
1
16
-
17
1
-
-
1
-
-
-
1
1
-
-
-
-
-
-
693949
Zhang
ACTX-8, a cytotoxic L-amino ac ...
Deinagkistrodon acutus
Life Sci.
80
1189-1197
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695208
Wei
Purification, characterization ...
Gloydius ussuriensis
Toxicon
50
1126-1139
2007
-
1
-
-
-
-
-
12
-
-
3
-
-
1
-
-
1
-
-
1
2
-
13
1
-
-
-
12
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
12
-
-
3
-
-
-
-
1
-
1
2
-
13
1
-
-
-
12
1
1
-
-
-
-
-
-
-
-
695209
Jin
Molecular characterization of ...
Bungarus fasciatus, Bungarus multicinctus, Naja atra, Ophiophagus hannah
Toxicon
50
479-489
2007
-
1
4
-
-
-
-
5
-
-
3
-
-
9
-
-
1
-
-
5
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
-
-
-
-
5
-
-
3
-
-
-
-
1
-
5
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695281
Gau
L-amino acid oxidases with spe ...
Gloeobacter violaceus PCC 7421, no activity in Anabaena variabilis ATCC 29413, no activity in Prochlorococcus marinus, no activity in Prochlorococcus marinus MED4, no activity in Prochlorococcus marinus MIT 9211, no activity in Prochlorococcus marinus MIT 9312, no activity in Prochlorococcus marinus MIT 9313, no activity in Prochlorococcus marinus NATL2A, no activity in Prochlorococcus marinus SS 120, no activity in Synechococcus sp., no activity in Synechococcus sp. CC9902, no activity in Synechococcus sp. JA-2-3B'a(2-13), no activity in Synechococcus sp. JA-3-3Ab, no activity in Synechococcus sp. RS9917, no activity in Synechococcus sp. WH 8102, no activity in Thermosynechococcus elongatus BP-1, Nostoc punctiforme PCC 73102, Nostoc sp. PCC 7120, Synechococcus cedrorum PCC 6908, Synechococcus elongatus PCC 6301, Synechococcus elongatus PCC 7942, Synechococcus sp. CC9605, Synechococcus sp. WH 5701, Synechococcus sp. WH 7805, Synechocystis sp. PCC 6803, Trichodesmium erythraeum IMS101
Z. Naturforsch. C
62
273-284
2007
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1
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3
3
9
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1
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26
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15
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3
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1
3
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1
3
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3
3
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3
9
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1
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15
-
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1
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667079
Faust
Crystallization and preliminar ...
Rhodococcus opacus
Acta crystallogr. Sect. F
62
279-281
2006
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1
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1
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1
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1
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1
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667235
Ande
Mechanisms of cell death induc ...
Calloselasma rhodostoma
Apoptosis
11
1439-1451
2006
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1
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667933
Izidoro
Biochemical and functional cha ...
Bothrops pirajai
Bioorg. Med. Chem.
14
7034-7043
2006
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-
-
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2
1
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15
-
1
1
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1
8
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9
1
1
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1
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1
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2
1
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1
1
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1
8
-
9
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
669893
Moustafa
Crystal structure of LAAO from ...
Calloselasma rhodostoma
J. Mol. Biol.
364
991-1002
2006
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1
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3
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1
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1
-
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669894
Faust
The structure of a bacterial l ...
Rhodococcus opacus
J. Mol. Biol.
367
234-248
2006
-
1
1
1
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1
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5
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1
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3
1
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1
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1
1
1
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1
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1
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3
1
-
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670964
Toyama
Isolation of a new L-amino aci ...
Crotalus durissus cascavella
Toxicon
47
47-57
2006
-
-
-
-
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2
1
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1
1
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1
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1
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2
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1
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1
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2
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1
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1
1
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1
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1
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2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
670968
Tonismaegi
L-amino acid oxidase from Vipe ...
Macrovipera lebetina
Toxicon
48
227-237
2006
-
-
-
-
-
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3
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3
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5
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1
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1
6
3
7
1
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1
4
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3
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3
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1
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1
6
3
7
1
-
-
1
4
-
-
-
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-
-
-
-
661038
Cooper
Aminotransferase, L-amino acid ...
Crotalus adamanteus
Biochem. Pharmacol.
69
209-220
2005
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1
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11
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11
-
-
-
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-
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-
-
-
-
-
-
-
-
667254
Davis
Amino acid catabolism by an ar ...
Aspergillus nidulans
Appl. Environ. Microbiol.
71
3551-3555
2005
-
-
1
-
1
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1
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1
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1
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-
-
-
-
667368
Findrik
-
Enzymatic activity of L-amino ...
Crotalus adamanteus
Biocatal. Biotransform.
23
315-321
2005
-
1
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1
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1
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1
-
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669658
Yang
Cloning, characterization and ...
Aplysia californica
J. Exp. Biol.
208
3609-3622
2005
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1
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1
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1
1
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9
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2
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1
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1
3
1
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1
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1
1
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1
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1
1
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2
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1
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1
3
1
-
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-
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-
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-
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-
-
-
-
670963
Butzke
Cloning and biochemical charac ...
Aplysia punctata
Toxicon
46
479-489
2005
-
-
1
-
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1
-
-
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2
1
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3
-
1
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1
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4
1
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3
-
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1
-
1
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1
1
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-
1
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2
1
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1
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1
-
-
4
1
-
-
3
-
-
-
-
1
-
-
-
-
-
-
654119
Zhang
Purification, partial characte ...
Gloydius halys
Acta Crystallogr. Sect. D
60
974-977
2004
-
-
-
1
-
-
-
1
-
-
1
-
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3
-
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1
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2
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1
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1
1
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1
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1
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1
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1
-
2
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
654954
Stabeli
Platelet aggregation and antib ...
Bothrops alternatus
Bioorg. Med. Chem.
12
2881-2886
2004
-
-
-
-
-
-
-
-
-
-
2
1
-
6
-
1
1
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
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-
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-
2
1
-
-
1
1
-
3
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
656435
Mason
IL-4-induced gene-1 is a leuko ...
Mus musculus
J. Immunol.
173
4561-4567
2004
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
1
-
-
-
1
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
1
-
-
-
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-
1
-
-
1
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
653762
Geueke
Heterologous expression of Rho ...
Rhodococcus opacus
Protein Expr. Purif.
28
303-309
2003
-
-
1
-
-
-
1
2
-
-
-
-
-
5
-
-
1
-
-
-
1
-
2
-
1
-
-
2
1
-
-
-
2
-
-
-
-
1
-
-
-
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-
1
2
2
-
-
-
-
-
-
-
1
-
-
2
-
2
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
654441
Zhang
Molecular characterization of ...
Trimeresurus stejnegeri
Biochem. Biophys. Res. Commun.
309
598-604
2003
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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1
1
-
-
-
-
-
-
-
-
-
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-
-
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-
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1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654872
Sakurai
Anticoagulant activity of M-LA ...
Gloydius blomhoffii
Biochim. Biophys. Acta
1649
51-57
2003
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655316
Iijima
L-amino acid oxidase activity ...
Dolabella auricularia
Dev. Comp. Immunol.
27
505-512
2003
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391781
Du
Snake venom L-amino acid oxida ...
Agkistrodon contortrix laticinctus, Bothrops moojeni, Calloselasma rhodostoma, Crotalus adamanteus, Crotalus atrox, Eristicophis macmahoni, Gloydius blomhoffii, Naja kaouthia, Ophiophagus hannah, Protobothrops flavoviridis, Protobothrops mucrosquamatus, Pseudechis australis, snake
Toxicon
40
659-665
2002
-
-
-
-
-
-
-
-
-
-
19
6
-
13
-
2
-
-
-
-
1
-
12
11
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
19
6
-
-
2
-
-
-
1
-
12
11
-
-
-
-
-
-
-
7
-
-
-
-
-
-
391817
Sun
Characterization and expressio ...
Mus musculus
J. Biol. Chem.
277
19080-19086
2002
-
-
1
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651026
Geueke
-
A new bacterial L-amino acid o ...
Rhodococcus opacus
Enzyme Microb. Technol.
31
77-87
2002
-
-
-
-
-
2
12
30
-
-
5
-
-
1
-
-
1
-
-
-
2
3
78
2
-
-
3
-
1
2
-
1
20
2
-
-
-
-
1
-
-
2
-
20
22
30
-
-
5
-
-
-
-
1
-
-
2
3
78
2
-
-
3
-
1
2
-
2
-
-
-
-
-
-
656581
Lu
L-amino acid oxidase from Trim ...
Protobothrops jerdonii
J. Nat. Toxins
11
345-352
2002
-
-
-
-
-
-
-
-
-
-
2
-
-
7
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391815
Macheroux
L-Amino-acid oxidase from the ...
Calloselasma rhodostoma
Eur. J. Biochem.
268
1679-1686
2001
-
-
1
-
-
-
1
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
391816
Geyer
Structure and characterization ...
Calloselasma rhodostoma
Eur. J. Biochem.
268
4044-4053
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391818
Pawelek
The structure of L-amino acid ...
Calloselasma rhodostoma
EMBO J.
19
4204-4215
2000
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391820
Ali
Isolation, structural, and fun ...
Eristicophis macmahoni
Arch. Biochem. Biophys.
384
216-226
2000
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391821
Souza
Isolation and structural chara ...
Agkistrodon contortrix laticinctus
Arch. Biochem. Biophys.
368
285-290
1999
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
9
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
9
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391822
Calderon
-
A Neurospora crassa mutant alt ...
Neurospora crassa
Microbiology
143
1969-1974
1997
-
-
-
-
1
-
-
-
-
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391826
Ahn
Characterization and cytotoxic ...
Ophiophagus hannah
Int. J. Biochem. Cell Biol.
29
911-919
1997
-
-
-
-
-
-
-
-
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-
1
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1
-
1
1
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1
1
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1
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1
1
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-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391823
Pessatti
Screening of Bothrops snake ve ...
Bothrops sp.
Appl. Biochem. Biotechnol.
51-52
197-210
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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1
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5
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1
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-
1
-
-
-
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-
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-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740597
Massad
Proteus mirabilis amino acid d ...
Proteus mirabilis, Proteus mirabilis HI4320
J. Bacteriol.
177
5878-5883
1995
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
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1
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1
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-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
391819
Ponnudurai
Purification and properties of ...
Calloselasma rhodostoma
Arch. Biochem. Biophys.
313
373-378
1994
-
-
-
-
-
-
-
15
-
-
2
-
-
1
-
1
1
-
-
-
-
-
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
15
-
-
2
-
-
-
1
1
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391824
Brearley
-
Purification and partial chara ...
Bacillus carotarum, Bacillus carotarum 2Pfa
Appl. Microbiol. Biotechnol.
41
670-676
1994
-
-
-
-
-
-
-
3
-
-
2
-
-
2
-
-
1
-
-
-
-
2
11
1
1
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
2
-
-
-
-
1
-
-
-
2
11
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
391825
Li
Purification and characterizat ...
Ophiophagus hannah
Toxicon
32
1349-1358
1994
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
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1
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1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391814
Vallon
Extensive accumulation of an e ...
Chlamydomonas reinhardtii
Eur. J. Biochem.
215
351-360
1993
1
-
-
-
-
-
5
1
1
-
4
1
-
2
-
1
1
-
-
-
23
-
2
1
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
5
-
1
1
-
4
1
-
-
1
1
-
-
23
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
391772
Tan
Isolation and characterization ...
Ophiophagus hannah
Biochem. Int.
19
937-944
1989
-
-
-
-
-
1
1
1
-
-
2
-
-
1
-
1
1
-
-
1
-
1
1
1
-
-
3
1
1
-
1
1
-
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
2
-
-
-
1
1
-
1
-
1
1
1
-
-
3
1
1
-
1
-
-
-
-
-
-
-
391810
Pistorius
-
Investigations abuot various p ...
Synechococcus elongatus PCC 7942
Z. Naturforsch. C
44
370-377
1989
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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-
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-
-
2
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-
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1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391773
Ueda
Purification and characterizat ...
Protobothrops mucrosquamatus
Toxicon
26
695-706
1988
-
-
-
-
-
2
9
1
-
1
2
-
-
1
-
-
1
-
-
1
-
1
17
1
-
-
3
-
3
-
3
1
-
-
-
-
-
-
1
-
-
2
-
9
-
1
-
1
2
-
-
-
-
1
-
1
-
1
17
1
-
-
3
-
3
-
3
-
-
-
-
-
-
-
391811
Meyer
-
Some properties of photosystem ...
Synechococcus sp.
Biochim. Biophys. Acta
893
426-433
1987
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
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-
-
-
-
-
-
-
-
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-
-
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-
1
-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391805
Pistorius
-
Further evidence for a functio ...
Synechococcus elongatus PCC 7942
Z. Naturforsch. C
40
806-813
1985
-
-
-
-
-
-
8
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391812
Cooper
Enzymatic oxidation of L-homoc ...
snake
Arch. Biochem. Biophys.
239
556-566
1985
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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-
-
-
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2
-
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-
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-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391779
Kimura
-
Action of S-carbamoyl and S-th ...
Crotalus adamanteus
Agric. Biol. Chem.
48
3157-3159
1984
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
-
-
2
-
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-
-
-
-
-
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-
-
-
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-
-
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-
-
-
-
-
-
-
-
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391806
Pistorius
Effects of Mn2+, Ca2+ and chlo ...
Synechococcus elongatus PCC 7942
Eur. J. Biochem.
135
217-222
1983
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391780
Szwajcer
-
Production of alpha-keto acids ...
Providencia sp., Providencia sp. PCM 1298
Enzyme Microb. Technol.
4
409-413
1982
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
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-
-
-
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-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391803
Sikora
Regulation of L-amino acid oxi ...
Neurospora crassa
Mol. Gen. Genet.
186
33-39
1982
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391807
Pistorius
Presence of an amino acid oxid ...
Synechococcus elongatus PCC 7942
Eur. J. Biochem.
126
203-209
1982
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391813
Christman
Essential arginine residues oc ...
snake
Experientia
38
537-538
1982
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391808
Pistorius
Some properties of a basic L-a ...
Synechococcus elongatus PCC 7942
Biochim. Biophys. Acta
611
227-240
1980
-
-
-
-
-
-
15
-
-
-
2
-
-
2
-
-
1
-
-
-
1
-
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
15
-
-
-
-
2
-
-
-
-
1
-
-
1
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391782
Couer
Reversible inactivation of L-a ...
Crotalus adamanteus
J. Biol. Chem.
252
8035-8039
1977
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
391809
Löffelhardt
-
The biosynthesis of phenylacet ...
Synechococcus elongatus PCC 7942
Z. Naturforsch. C
32
345-350
1977
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391783
Marcotte
Vinylglycine and proparglyglyc ...
Crotalus adamanteus
Biochemistry
15
3070-3076
1976
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
389803
Bright
-
Flavoprotein oxidases ...
Agkistrodon piscivorus piscivorus, Crotalus adamanteus
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
421-505
1975
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391784
Coudert
Charcterization and physiologi ...
Corynebacterium sp., Corynebacterium sp. A20, no activity in Bacillus subtilis subsp. subtilis, no activity in Bacillus subtilis subsp. subtilis NCIB 3610, no activity in Escherichia coli, no activity in Pseudomonas putida, no activity in Pseudomonas putida T1
Arch. Microbiol.
102
151-153
1975
-
-
-
-
-
2
1
3
1
-
1
2
-
8
-
-
-
-
-
-
-
1
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
3
1
-
1
2
-
-
-
-
-
-
-
1
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391785
Duerre
L-amino acid oxidases of Prote ...
Providencia rettgeri
J. Bacteriol.
121
656-663
1975
-
-
-
-
-
-
-
12
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391768
Cioaca
Bacterial amino acid oxidases. ...
no activity in Acinetobacter anitratum, no activity in Alcaligenes faecalis, no activity in Bacillus subtilis, no activity in Diplococcus pneumoniae, no activity in Enterobacter aerogenes, no activity in Klebsiella pneumoniae, no activity in Micrococcus tetragenus, no activity in Moraxella catarrhalis, no activity in Mycobacterium phlei, no activity in Pseudomonas aeruginosa, no activity in Serratia marcescens, no activity in Shigella flexneri, no activity in Staphylococcus aureus, no activity in Staphylococcus epidermidis, no activity in Streptococcus viridans, Proteus sp., Providencia sp.
Arch. Roum. Pathol. Exp. Microbiol.
33
211-222
1974
-
-
-
-
-
-
10
-
2
-
-
-
-
17
-
-
-
-
-
-
-
2
28
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
2
28
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
391804
Cooper
Action of liver glutamine tran ...
Crotalus adamanteus
J. Biol. Chem.
248
8499-8505
1973
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391786
Pelmont
L-Amino acid oxidases of Prote ...
Proteus mirabilis
Biochimie
54
1359-1374
1972
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1
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2
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391787
Aurich
Purification and properties of ...
Neurospora crassa
Acta Biol. Med. Ger.
28
209-220
1972
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-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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2
1
1
1
-
1
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1
1
-
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391769
Nakano
-
L-Amino acid oxidase (rat kidn ...
Rattus norvegicus
Methods Enzymol.
17B
601-605
1971
-
-
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1
-
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1
-
1
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1
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1
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1
1
1
7
-
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2
2
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1
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1
1
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1
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1
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1
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1
1
1
7
-
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2
2
-
-
-
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-
-
-
-
-
391770
Weller
-
L-Amino acid oxidase (snake ve ...
Crotalus adamanteus
Methods Enzymol.
17B
597-600
1971
-
-
-
1
-
-
1
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1
1
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1
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1
1
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1
1
1
12
-
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1
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1
1
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1
1
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1
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1
1
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1
1
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1
1
1
12
-
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1
-
1
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-
391771
Weller
-
Assay of amino acid oxidase ...
snake
Methods Enzymol.
17B
593-596
1971
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1
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1
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2
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391775
Chen
-
Oxidative deamination of sulfu ...
Crotalus terrificus terrificus, Providencia rettgeri
Arch. Biochem. Biophys.
146
51-63
1971
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17
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2
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2
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9
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5
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17
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2
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9
-
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5
-
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391788
Luppa
Kinetic studies on the reactio ...
Neurospora crassa
Acta Biol. Med. Ger.
27
839-850
1971
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-
-
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2
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1
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1
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1
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2
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1
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1
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391790
Page
L-Amino acid oxidase. II. Deut ...
Crotalus adamanteus
Biochim. Biophys. Acta
227
16-31
1971
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1
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1
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-
1
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391789
Mizon
Properties of turkey (Meleagri ...
Meleagris gallopavo
Biochim. Biophys. Acta
212
33-42
1970
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-
-
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1
8
1
2
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1
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1
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1
1
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9
-
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1
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1
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1
-
8
1
2
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1
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1
1
-
9
-
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-
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-
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-
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391791
Skarnes
L-Amino-acid oxidase, a bacter ...
Crotalus adamanteus
Nature
225
1072-1073
1970
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1
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1
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1
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3
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1
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1
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1
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1
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3
-
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1
-
1
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391792
Hayes
Microheterogeneity of L-amino ...
Crotalus adamanteus
J. Biol. Chem.
244
6636-6644
1969
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1
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2
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2
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1
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391793
Page
L-Amino-acid oxidase. I. Effec ...
Crotalus adamanteus
Biochim. Biophys. Acta
191
38-45
1969
-
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1
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1
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1
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1
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1
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391794
Nakano
Distribution and immunochemica ...
Rattus norvegicus
Biochim. Biophys. Acta
185
19-30
1969
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3
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2
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2
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1
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3
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2
-
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1
-
-
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391795
Porter
Location of hydrogen transfer ...
Crotalus adamanteus
Biochem. Biophys. Res. Commun.
36
209-214
1969
-
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1
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1
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1
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-
-
1
-
-
-
-
-
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-
-
-
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-
-
-
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391796
Miller
Oxidative deamination of S-ade ...
Rattus norvegicus
J. Biol. Chem.
244
4273-4276
1969
-
-
-
-
-
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1
-
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1
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1
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2
1
-
2
-
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-
-
1
-
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-
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-
-
-
-
-
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-
1
-
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-
-
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1
-
2
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
391797
De Kok
Studies on L-amino acid oxidas ...
Crotalus adamanteus
Biochemistry
8
1405-1411
1969
-
-
-
-
-
-
-
-
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-
2
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1
-
1
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1
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1
1
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-
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2
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1
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1
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
-
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391776
Curti
Inactivation of snake venom L- ...
Crotalus adamanteus
J. Biol. Chem.
243
2306-2314
1968
-
-
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2
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1
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1
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2
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1
-
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-
-
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-
-
-
-
-
-
-
-
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391798
Nakano
Molecular weight of mammalian ...
Rattus norvegicus
Biochim. Biophys. Acta
168
156-157
1968
-
-
-
-
-
-
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1
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2
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2
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1
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1
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1
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391799
De Kok
Studies on L-amino-acid oxidas ...
Crotalus adamanteus
Biochim. Biophys. Acta
167
35-47
1968
-
-
-
-
-
-
22
-
-
-
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1
-
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1
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-
1
-
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-
-
-
-
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-
-
20
-
-
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-
-
-
-
-
-
-
22
20
-
-
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-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391800
Koster
The relation between temperatu ...
Crotalus adamanteus
Biochim. Biophys. Acta
167
48-63
1968
-
-
-
-
-
-
2
-
-
-
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1
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1
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1
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-
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2
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391777
Paik
Studies on the stability of L- ...
Crotalus adamanteus
Biochim. Biophys. Acta
139
49-55
1967
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
-
-
-
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
391778
Massey
On the reaction mechanism of C ...
Crotalus adamanteus
J. Biol. Chem.
242
1259-1264
1967
-
-
-
-
-
-
-
-
-
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1
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-
1
-
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1
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1
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-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
391801
Shinwari
-
Naturally occuring inhibition ...
Gallus gallus
Biochem. J.
104
538-548
1967
-
-
-
-
-
-
1
1
-
-
-
-
-
1
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1
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-
1
-
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-
1
-
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-
-
-
-
-
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1
-
1
-
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-
-
-
-
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-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
391802
Nakano
Crystalline L-amino-acid oxida ...
Rattus norvegicus
Biochim. Biophys. Acta
139
40-48
1967
-
-
-
1
-
-
2
-
2
-
-
-
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1
-
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1
-
-
1
1
-
10
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
2
-
-
2
-
-
-
-
-
-
1
-
1
1
-
10
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
391766
Meister
-
Flavoprotein amino acid oxidas ...
Agkistrodon piscivorus piscivorus, Crotalus adamanteus, Rattus norvegicus
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
609-648
1963
-
-
-
2
-
-
10
-
-
-
2
-
-
3
-
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3
3
-
4
-
-
11
-
-
-
1
-
3
-
-
3
-
-
-
-
-
-
3
2
-
-
-
10
-
-
-
-
2
-
-
-
-
3
-
4
-
-
11
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
391774
Wellner
Crystalline L-amino acid oxida ...
Crotalus adamanteus
J. Biol. Chem.
235
2013-2018
1960
-
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1
-
-
-
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2
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1
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1
-
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1
-
-
1
-
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-
2
-
1
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
1
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1
-
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2
-
1
-
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-