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Literature summary for 1.4.3.16 extracted from

  • Messner, K.R.; Imlay, J.A.
    Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase (2002), J. Biol. Chem., 277, 42563-42571.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate + H2O + fumarate Escherichia coli it is very likely, that fumarate and not O2 is the physiological electron acceptor in vivo oxaloacetate + NH3 + succinate
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate + H2O + fumarate
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Escherichia coli oxaloacetate + NH3 + succinate
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L-aspartate + H2O + fumarate it is very likely, that fumarate and not O2 is the physiological electron acceptor in vivo Escherichia coli oxaloacetate + NH3 + succinate
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?
L-aspartate + H2O + O2 oxidation is accelerated in the presence of 0.5 mM fumarate, fumarate appears to be the preferred electron acceptor since its presence inhibits oxygen reduction by 90% Escherichia coli oxaloacetate + NH3 + H2O2
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Cofactor

Cofactor Comment Organism Structure
FAD
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Escherichia coli