Literature summary for 1.4.3.13 extracted from

Wiel, C.; Augert, A.; Vincent, D.F.; Gitenay, D.; Vindrieux, D.; Le Calve, B.; Arfi, V.; Lallet-Daher, H.; Reynaud, C.; Treilleux, I.; Bartholin, L.; Lelievre, E.; Bernard, D.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis (2013), Cell Death Dis., 4, e855 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
beta-aminopropionitrile	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
peptidyl-L-lysyl-peptide + O2 + H2O	Homo sapiens	-	peptidyl-allysyl-peptide + NH3 + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzylamine + O2 + H2O	-	Homo sapiens	benzaldehyde + NH3 + H2O2	-	?
peptidyl-L-lysyl-peptide + O2 + H2O	-	Homo sapiens	peptidyl-allysyl-peptide + NH3 + H2O2	-	?

Subunits

Subunits	Comment	Organism
?	x * 30000, LOX protein, SDS-PAGE	Homo sapiens
?	x * 80000, LOXL2 protein, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
LOX	-	Homo sapiens
Loxl2	-	Homo sapiens
lysyl oxidase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	inhibition of lysyl oxidase activity stabilizes oncogenic stress-induced senescence, delays tumorigenesis, and increases survival	Homo sapiens
physiological function	the enzyme participates in primary tumor growth by directly impacting the senescence stability	Homo sapiens

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Release 2023.1 (January 2023)