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Literature summary for 1.4.3.13 extracted from

  • Hutchinson, J.H.; Rowbottom, M.W.; Lonergan, D.; Darlington, J.; Prodanovich, P.; King, C.D.; Evans, J.F.; Bain, G.
    Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors the identification of an inhibitor selective for LOXL2 over LOX (2017), ACS Med. Chem. Lett., 8, 423-427 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Inhibitors

Inhibitors Comment Organism Structure
(2-chloropyridin-4-yl)methanamine
-
 Homo sapiens
1-(2-chloropyridin-4-yl)methanamine
-
 Homo sapiens
1-(2-fluoropyridin-4-yl)methanamine
-
 Homo sapiens
1-(2-methoxypyridin-4-yl)methanamine
-
 Homo sapiens
1-(2-phenoxypyridin-4-yl)methanamine
-
 Homo sapiens
1-(3-fluoropyridin-4-yl)methanamine
-
 Homo sapiens
1-(4-fluorophenyl)methanamine
-
 Homo sapiens
1-(4-methoxyphenyl)methanamine
-
 Homo sapiens
1-(4-nitrophenyl)methanamine
-
 Homo sapiens
1-(pyridin-4-yl)methanamine
-
 Homo sapiens
1-(quinolin-4-yl)methanamine
-
 Homo sapiens
1-([2,3'-bipyridin]-4-yl)methanamine
-
 Homo sapiens
1-phenylmethanamine
-
 Homo sapiens
1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine
-
 Homo sapiens
1-[2-(trifluoromethyl)pyridin-4-yl]methanamine
-
 Homo sapiens
1-[3-(hydrazinylmethyl)phenyl]methanamine
-
 Homo sapiens
1-[4-(1,3-thiazol-2-yl)phenyl]methanamine
-
 Homo sapiens
1-[4-(hydrazinylmethyl)phenyl]methanamine
-
 Homo sapiens
1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine
-
 Homo sapiens
2-(pyridin-4-yl)ethan-1-amine
-
 Homo sapiens
2-phenylcyclopropan-1-amine
-
 Homo sapiens
2-phenylethan-1-amine
-
 Homo sapiens
3-aminopropanenitrile
-
 Homo sapiens
4-(aminomethyl)aniline
-
 Homo sapiens
4-(aminomethyl)benzonitrile
-
 Homo sapiens
beta-aminopropionitrile
-
 Homo sapiens
methyl 3-(aminomethyl)benzoate
-
 Homo sapiens
methyl 4-(aminomethyl)benzoate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
LOR2
-
 Homo sapiens
LOX
-
 Homo sapiens
Loxl2
-
 Homo sapiens
lysyl oxidase homolog 2
-
 Homo sapiens
lysyl oxidase-like 2
-
 Homo sapiens
protein-L-lysine:oxygen 6-oxidoreductase
-
 Homo sapiens
protein-lysine 6-oxidase
-
 Homo sapiens
WS9-14
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000066
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens beta-aminopropionitrile
0.000066
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 3-aminopropanenitrile
0.000126
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens (2-chloropyridin-4-yl)methanamine
0.000126
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(2-chloropyridin-4-yl)methanamine
0.000203
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine
0.000309
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(2-phenoxypyridin-4-yl)methanamine
0.000321
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-([2,3'-bipyridin]-4-yl)methanamine
0.000385
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(2-fluoropyridin-4-yl)methanamine
0.000431
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(3-fluoropyridin-4-yl)methanamine
0.00067
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 4-(aminomethyl)benzonitrile
0.000719
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(4-nitrophenyl)methanamine
0.000902
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[4-(1,3-thiazol-2-yl)phenyl]methanamine
0.000999
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[2-(trifluoromethyl)pyridin-4-yl]methanamine
0.00111
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[4-(hydrazinylmethyl)phenyl]methanamine
0.00118
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(2-methoxypyridin-4-yl)methanamine
0.00122
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(pyridin-4-yl)methanamine
0.00354
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens methyl 3-(aminomethyl)benzoate
0.00362
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens methyl 4-(aminomethyl)benzoate
0.00497
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[3-(hydrazinylmethyl)phenyl]methanamine
0.00604
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(quinolin-4-yl)methanamine
0.00821
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 2-(pyridin-4-yl)ethan-1-amine
0.026
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(4-fluorophenyl)methanamine
0.031
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine
0.035
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-(4-methoxyphenyl)methanamine
0.047
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 4-(aminomethyl)aniline
0.0601
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 2-phenylethan-1-amine
0.0647
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 1-phenylmethanamine
0.1
-
 LOXL2 protein, at pH 8.0 and 37°C Homo sapiens 2-phenylcyclopropan-1-amine