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Literature summary for 1.4.3.13 extracted from

  • Xu, L.; Go, E.P.; Finney, J.; Moon, H.; Lantz, M.; Rebecchi, K.; Desaire, H.; Mure, M.
    Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells (2013), J. Biol. Chem., 288, 5357-5363.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Drosophila melanogaster Schneider-2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
N455Q the mutant protein is not secreted into the medium since the mutation prevents N-glycosylation, so the proteins fail to fold properly and undergo rapid degradation Homo sapiens
N644Q the mutant protein is not secreted into the medium since the mutation prevents N-glycosylation, so the proteins fail to fold properly and undergo rapid degradation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4K0
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycans at Asn-455 and Asn-644 are essential for proper folding and secretion of the enzyme. The N-glycan at Asn-644 enhances the solubility and stability of the enzyme catalytic domain Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
?
tropoelastin + H2O + O2
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Loxl2
-
Homo sapiens
lysyl oxidase-like 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
lysyl-tyrosyl quinone Lys-653 and Tyr-689 are the precursor residues for the lysyl-tyrosyl quinone cofactor of the enzyme Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is highly up-regulated in metastatic breast cancer cells and tissues up

General Information

General Information Comment Organism
physiological function the enzyme induces epithelial-to-mesenchymal transition, the first step of metastasis/invasion Homo sapiens