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Literature summary for 1.4.3.13 extracted from

  • Saad, F.A.; Torres, M.; Wang, H.; Graham, L.
    Intracellular lysyl oxidase: effect of a specific inhibitor on nuclear mass in proliferating cells (2010), Biochem. Biophys. Res. Commun., 396, 944-949.
    View publication on PubMed
Search for more literature for 1.4.3.13

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation Homo sapiens
beta-aminopropionitrile a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular
-
 Rattus norvegicus
-
-
nucleus
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 Homo sapiens 5634
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nucleus quantitative expression analysis of LOX isozymes, overview Rattus norvegicus 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens P28300
-
-
Rattus norvegicus P16636 isozymes LOX1, LOXL2, LOXL3, and LOXL4
-

Source Tissue

Source Tissue Comment Organism Textmining
A7r5 cell smooth muscle cells Rattus norvegicus
-
additional information quantitative expression analysis of LOX isozymes in different subcellular compartments in PC-12 cells, overview Rattus norvegicus
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PC-12 cell apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC-12 cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC-12 cells Rattus norvegicus ?
-
 ?
additional information apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC12 cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
LOX
-
 Homo sapiens
LOX
-
 Rattus norvegicus
lysyl oxidase
-
 Homo sapiens
lysyl oxidase
-
 Rattus norvegicus

General Information

General Information Comment Organism
additional information LOX expression opposes the effect of mutationally activated Ras, which is present in about 30% of human cancers. Proliferating cells dramatically increase their nuclear protein content when exposed to beta-aminopropionitrile, a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation Homo sapiens
physiological function LOX is the principal enzyme involved in crosslinking of collagen. Nuclear lysyl oxidase probably regulates nuclear growth, and thereby modulates cell proliferation, overview Homo sapiens
physiological function LOX is the principal enzyme involved in crosslinking of collagen. Nuclear lysyl oxidase probably regulates nuclear growth, and thereby modulates cell proliferation, overview Rattus norvegicus