Application | Comment | Organism |
---|---|---|
medicine | LOX inhibition might be useful in metastasis prevention, metastasis model and drug administration study in mice, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Aminopropionitrile | i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231 | Homo sapiens | |
beta-aminopropionitrile | a specific lysyl oxidase inhibitor, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P28300 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | circulating | Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-231-Luc2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Homo sapiens |
lysyl oxidase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview. LOX inhibition might be useful in metastasis prevention | Homo sapiens |
physiological function | the extracellular matrix remodeling enzyme has a role in promoting breast cancer cell motility and invasiveness. LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, metastasis model and drug administration study in mice, overview | Homo sapiens |