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Literature summary for 1.4.3.13 extracted from

  • Atsawasuwan, P.; Mochida, Y.; Katafuchi, M.; Kaku, M.; Fong, K.S.; Csiszar, K.; Yamauchi, M.
    Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity (2008), J. Biol. Chem., 283, 34229-34240.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Cloned(Commentary)

Cloned (Comment) Organism
expression of proenzyme, mature enzyme, isolated propeptide, and mutant enzymes in HEK-293 cells as HA-tagged proteins Mus musculus

Protein Variants

Protein Variants Comment Organism
K314A site-directed mutagenesis Mus musculus
Y349F site-directed mutagenesis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular mature LOX and mature TGF-beta1 are colocalized in the extracellular matrix in an osteoblastic cell culture system Mus musculus
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Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
bone matrix mineral-associated fraction Mus musculus
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osteoblast cell line
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
LOX
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 Mus musculus
lysyl oxidase
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
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 assay at Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme binds to mature TGF-beta1 and enzymatically regulates its signaling in bone and plays an important role in bone maintenance and remodeling Mus musculus