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Literature summary for 1.4.3.13 extracted from

  • Payne, S.L.; Hendrix, M.J.; Kirschmann, D.A.
    Paradoxical roles for lysyl oxidases in cancer - a prospect (2007), J. Cell. Biochem., 101, 1338-1354.
    View publication on PubMed

Application

Application Comment Organism
medicine LOX is a potent metastasis-promoting gene in breast carcinomas that facilitates metastatic tumor progression by inducing cell motility and migration and has the potential for novel anti-metastatic cancer therapeutics Mus musculus
medicine LOX is a potent metastasis-promoting gene in breast carcinomas that facilitates metastatic tumor progression by inducing cell motility and migration and has the potential for novel anti-metastatic cancer therapeutics Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile irreversible, competitive inhibitor Homo sapiens
beta-aminopropionitrile irreversible, competitive inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ essential Mus musculus
Cu2+ essential Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
ProLOX is subsequently cleaved into its catalytically mature 32000Da protein (LOX) and an 18000 Da LOX-propeptide Mus musculus
32000
-
ProLOX is subsequently cleaved into its catalytically mature 32000Da protein (LOX) and an 18000 Da LOX-propeptide Homo sapiens
50000
-
N-glycosylated and secreted from the cell as a catalytically inactive 50000 Da proenzyme protein (proLOX) Mus musculus
50000
-
N-glycosylated and secreted from the cell as a catalytically inactive 50000 Da proenzyme protein (proLOX) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amnion LOX is highly expressed in early gestational amnion tissue (12-14 weeks) Mus musculus
-
breast carcinoma cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
HNSCC cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
prostate adenocarcinoma cell
-
Homo sapiens
-
renal cell carcinoma cell
-
Homo sapiens
-
vascular smooth muscle cell
-
Mus musculus
-
vascular smooth muscle cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues Mus musculus ?
-
?
additional information catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues Homo sapiens ?
-
?
additional information purified LOX readily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8 Mus musculus ?
-
?
additional information purifiedLOXreadily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8 Homo sapiens ?
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
-
Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
-
Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
LOX
-
Mus musculus
LOX
-
Homo sapiens
lysyl oxidase
-
Mus musculus
lysyl oxidase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
lysyl-tyrosyl-quinone
-
Mus musculus
lysyl-tyrosyl-quinone
-
Homo sapiens