Application | Comment | Organism |
---|---|---|
medicine | LOX is a potent metastasis-promoting gene in breast carcinomas that facilitates metastatic tumor progression by inducing cell motility and migration and has the potential for novel anti-metastatic cancer therapeutics | Mus musculus |
medicine | LOX is a potent metastasis-promoting gene in breast carcinomas that facilitates metastatic tumor progression by inducing cell motility and migration and has the potential for novel anti-metastatic cancer therapeutics | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-aminopropionitrile | irreversible, competitive inhibitor | Homo sapiens | |
beta-aminopropionitrile | irreversible, competitive inhibitor | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | essential | Mus musculus | |
Cu2+ | essential | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
ProLOX is subsequently cleaved into its catalytically mature 32000Da protein (LOX) and an 18000 Da LOX-propeptide | Mus musculus |
32000 | - |
ProLOX is subsequently cleaved into its catalytically mature 32000Da protein (LOX) and an 18000 Da LOX-propeptide | Homo sapiens |
50000 | - |
N-glycosylated and secreted from the cell as a catalytically inactive 50000 Da proenzyme protein (proLOX) | Mus musculus |
50000 | - |
N-glycosylated and secreted from the cell as a catalytically inactive 50000 Da proenzyme protein (proLOX) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amnion | LOX is highly expressed in early gestational amnion tissue (12-14 weeks) | Mus musculus | - |
breast carcinoma cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
HNSCC cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
prostate adenocarcinoma cell | - |
Homo sapiens | - |
renal cell carcinoma cell | - |
Homo sapiens | - |
vascular smooth muscle cell | - |
Mus musculus | - |
vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues | Mus musculus | ? | - |
? | |
additional information | catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues | Homo sapiens | ? | - |
? | |
additional information | purified LOX readily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8 | Mus musculus | ? | - |
? | |
additional information | purifiedLOXreadily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8 | Homo sapiens | ? | - |
? | |
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Mus musculus | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Homo sapiens | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Mus musculus |
LOX | - |
Homo sapiens |
lysyl oxidase | - |
Mus musculus |
lysyl oxidase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
lysyl-tyrosyl-quinone | - |
Mus musculus | |
lysyl-tyrosyl-quinone | - |
Homo sapiens |